Objective To investigate the expression of FKBP prolyl isomerase 10(FKBP10)and type I collagen al-pha 1 chain(COL1A1)in renal carcinoma tissue and the prognostic factors.Method A total of 65 patients with renal car-cinoma were selected,and the expression levels of FKBP10,COL1A1 mRNA in renal carcinoma tissues were detected by quantitative polymerase chain reaction(qPCR).According to the follow-up results,they were divided into good prognosis group and poor prognosis group,the expression levels of FKBP10,COL1A1 mRNA in two groups were compared.The in-fluencing factors of poor prognosis in renal carcinoma patients were analyzed using Cox regression model.Result Dur-ing 1-year follow-up,among 65 patients with renal carcinoma,20 cases had poor prognosis and 45 cases had good prog-nosis.The expression levels of FKBP10,COL1A1 mRNA in poor prognosis group were significantly higher than those in good prognosis group,and the differences were statistically significant(P<0.01).Univariate analysis results showed that tumor size,TNM stage,pathological type,FKBP10 expression,and COL1A1 expression may be influencing factors of poor prognosis in renal carcinoma patients(P<0.05).Multivariate analysis results showed that high expression of FK-BP10 and COL1A1 were independent risk factors for poor prognosis in renal carcinoma patients(P<0.05).Conclusion The high expression of FKBP10 and COL1A1 are closely related to poor prognosis of patients with renal carcinoma,and both are independent risk factors for poor prognosis.
renal carcinomaFKBP prolyl isomerase 10collagen type I alpha 1 chainprognosisinfluencing factor
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