FKBP脯氨酰异构酶10、Ⅰ型胶原蛋白α1链在肾癌组织中的表达及预后影响因素分析
Expression of FKBP prolyl isomerase 10 and type I collagen alpha 1 chain in renal carcinoma tissue and prognostic factors analysis
葛玉坤 1胡容珲 2杨红艳 3韩露露 2王磊1
作者信息
- 1. 新乡市中心医院 泌尿外科 河南 新乡 453000;新乡市中心医院 泌尿肾病临床医学与药理研究重点实验室,河南 新乡 453000
- 2. 新乡医学院第四临床学院,河南 新乡 453000
- 3. 新乡市中心医院 泌尿外科 河南 新乡 453000
- 折叠
摘要
目的 探讨FKBP脯氨酰异构酶10(FKBP10)、Ⅰ型胶原蛋白α1链(COL1A1)在肾癌组织中的表达及预后影响因素.方法 选取 65 例肾癌患者,采用定量聚合酶链反应(qPCR)法检测肾癌组织中FKBP10、COL1A1 mRNA表达水平,根据随访结果分为预后良好组和预后不良组,比较两组患者的FKBP10、COL1A1 mRNA表达水平;肾癌患者预后不良的影响因素采用Cox回归模型分析.结果 随访1年,65例肾癌患者中,预后不良20例,预后良好45例.预后不良组肾癌患者肾癌组织中FKBP10、COL1A1 mRNA表达水平均明显高于预后良好组,差异均有统计学意义(P﹤0.01).单因素分析结果显示,肿瘤大小、TNM分期、病理类型、FKBP10表达情况、COL1A1表达情况均可能是肾癌患者预后不良的影响因素(P﹤0.05);多因素分析结果显示,FKBP10、COL1A1高表达均是肾癌患者预后不良的独立危险因素(P﹤0.05).结论 FKBP10、COL1A1高表达与肾癌患者的预后不良有关,且均是肾癌患者预后不良的独立危险因素.
Abstract
Objective To investigate the expression of FKBP prolyl isomerase 10(FKBP10)and type I collagen al-pha 1 chain(COL1A1)in renal carcinoma tissue and the prognostic factors.Method A total of 65 patients with renal car-cinoma were selected,and the expression levels of FKBP10,COL1A1 mRNA in renal carcinoma tissues were detected by quantitative polymerase chain reaction(qPCR).According to the follow-up results,they were divided into good prognosis group and poor prognosis group,the expression levels of FKBP10,COL1A1 mRNA in two groups were compared.The in-fluencing factors of poor prognosis in renal carcinoma patients were analyzed using Cox regression model.Result Dur-ing 1-year follow-up,among 65 patients with renal carcinoma,20 cases had poor prognosis and 45 cases had good prog-nosis.The expression levels of FKBP10,COL1A1 mRNA in poor prognosis group were significantly higher than those in good prognosis group,and the differences were statistically significant(P<0.01).Univariate analysis results showed that tumor size,TNM stage,pathological type,FKBP10 expression,and COL1A1 expression may be influencing factors of poor prognosis in renal carcinoma patients(P<0.05).Multivariate analysis results showed that high expression of FK-BP10 and COL1A1 were independent risk factors for poor prognosis in renal carcinoma patients(P<0.05).Conclusion The high expression of FKBP10 and COL1A1 are closely related to poor prognosis of patients with renal carcinoma,and both are independent risk factors for poor prognosis.
关键词
肾癌/FKBP脯氨酰异构酶10/Ⅰ型胶原蛋白α1链/预后/影响因素Key words
renal carcinoma/FKBP prolyl isomerase 10/collagen type I alpha 1 chain/prognosis/influencing factor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据