Effects of laparoscopic radical surgery on gastrointestinal function,immune function and inflammatory response in patients with colorectal cancer
Objective To explore the effects of laparoscopic radical surgery on gastrointestinal function,immune function and inflammatory response in patients with colorectal cancer.Method According to the different surgical meth-ods,112 colorectal cancer patients were divided into the open group and the laparoscopic group,with 56 cases in each group.The patients in the open group underwent open radical surgery,while patients in the laparoscopic group underwent laparoscopic radical surgery.The surgery related indexes,gastrointestinal function indexes[epidermal growth factor(EGF),vasoactive intestinal peptide(VIP),substance P,motilin,gastrin],inflammatory factors indexes[C-reactive pro-tein(CRP),procalcitonin(PCT),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],nutritional status indexes[hemo-globin(Hb),retinol-binding protein(RBP),transferrin(TRF),prealbumin(PAB),albumin(ALB)]and immune function indexes[lymphocyte count,neutrophil count,helper T cell(Th)1/Th2,CD4+/CD8+]were compared between the two groups.Result The operation time in laparoscopic group was significantly longer than that in open group,and the intra-operative blood loss was significantly less than that in open group,the recovery time of bowel sounds,first exhaust time,first defecation time,first time getting out of bed,and hospitalization time were significantly shorter than those in open group,and the differences were statistically significant(P<0.01).Three days after surgery,the levels of EGF,substance P,VIP,CRP,PCT,TNF-α,IL-6,and neutrophil count in laparoscopic group were lower than those in open group,while the levels of motilin,gastrin,Hb,RBP,TRF,PAB,ALB,and lymphocyte count,Th1/Th2,CD4+/CD8+were higher than those in open group,and the differences were statistically significant(P<0.05).Conclusion Laparoscopic radical surgery is beneficial for promoting the recovery of gastrointestinal function in colorectal cancer patients,and can reduce inflammato-ry reactions,improve immune function and nutritional status.
colorectal cancerlaparoscopic radical surgerygastrointestinal functioninflammatory reactionimmune function
万方数据
维普
