Objective To investigate the application effect of uncut-Roux-en-Y anastomosis in laparoscopic D2 radi-cal surgery for distal gastric cancer patients.Method A total of 87 patients with gastric cancer were selected and under-went laparoscopic D2 radical surgery.They were divided into observation group(n=45)and control group(n=42)accord-ing to the different anastomosis methods.The observation group underwent uncut-Roux-en-Y anastomosis for gastrointes-tinal reconstruction,while the control group underwent Billroth II anastomosis for gastrointestinal reconstruction.The in-traoperative indexes,postoperative recovery indexes,nutritional indexes[albumin(ALB),hemoglobin(Hb)and transfer-rin(TRF)]and incidence of postoperative complications were compared between the two groups.Result The surgical time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05);there were no statistically significant differences in the reconstruction time of the digestive tract,intraoperative bleeding volume,first ventilation time,and gastric tube removal time between the two groups(P>0.05).After surgery,the levels of ALB,Hb,and TRF in both groups were higher than before surgery,the ALB level in the observation group was higher than that in the control group,and the differences were statistically significant(P<0.05);there were no statistically significant differences in Hb and TRF levels between the two groups(P>0.05).Both groups did not experience infection after surgery,the total incidence of complications in the observation group was 11.11%,which was lower than 30.95%in the control group,and the difference was statistically significant(P<0.05).Conclusion The uncut-Roux-en-Y anastomosis for gastrointestinal reconstruction in laparoscopic D2 radical surgery for distal gastric cancer patients not only helps to shorten the operation time and hospitalization time,but also effectively im-proves the postoperative nutritional status of patients and reduces postoperative complications.