Expression of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta protein in colorectal cancer tissues and prognostic factors analysis
Expression of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta protein in colorectal cancer tissues and prognostic factors analysis
Objective To investigate the expression of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic sub-unit beta(PIK3CB)protein in colorectal cancer tissues and the prognostic factors.Method A total of 153 patients with colorectal cancer were selected,and their colorectal tissues and corresponding adjacent tissues were collected.The expres-sion of PIK3CB protein was detected by immunohistochemistry,and the expression of PIK3CB protein in colorectal can-cer tissues of colorectal cancer patients with different clinical characteristics were compared.The prognostic factors of colorectal cancer patients were analyzed using binary Logistic regression.Result The positive expression rate of PIK3CB protein in colorectal cancer tissues was 75.16%,which was significantly higher than 26.14%in adjacent tissues,and the difference was statistically significant(P<0.01).The positive expression rates of PIK3CB in colorectal cancer tis-sues of colorectal cancer patients with low to moderate differentiation,TNM stage III,lymph node metastasis,and distant metastasis were higher than those of patients with high differentiation,TNM stage I-II,no lymph node metastasis,and no distant metastasis,and the differences were statistically significant(P<0.05).At the end of follow-up,among 153 patients with colorectal cancer,41 cases had poor prognosis and 112 cases had good prognosis.Binary Logistic regression analy-sis showed that TNM stage III,lymph node metastasis,and PIK3CB positive expression were independent risk factors for poor prognosis in colorectal cancer patients(P<0.05).Conclusion The positive expression rate of PIK3CB protein is rel-atively high in colorectal cancer tissues,and the positive expression of PIK3CB is an independent risk factor for poor prognosis in colorectal cancer patients.
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