Therapeutic effect of nivolumab combined with chemotherapy on patients with advanced gastric cancer and its relationship with vascular endothelial growth factor and tumor necrosis factor-α levels
Objective To investigate the therapeutic effect of nivolumab combined with chemotherapy on patients with advanced gastric cancer and its relationship with vascular endothelial growth factor(VEGF)and tumor necrosis fac-tor-α(TNF-α)levels.Method According to different treatment methods,110 patients with advanced gastric cancer were divided into control group(n=58)and combination group(n=52).Patients in the control group received chemotherapy,and patients in the combination group received nivolumab combined with chemotherapy.The clinical efficacy and ad-verse reactions were compared between the two groups.According to the clinical efficacy,patients in the combination group were divided into effective group(complete response,partial response,stable disease)and ineffective group(pro-gressive disease),and the serum levels of VEGF and TNF-α were compared between the two groups.Point-biserial corre-lation analysis was used to analyze the correlation between serum VEGF,TNF-α levels and therapeutic effect in the com-bination group.Result The disease control rate of the combination group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Among 52 patients in the combination group,37 cases were effective and 15 cases were ineffective after treatment.The serum levels of VEGF and TNF-α in the ineffective group were significantly higher than those in the effective group,and the differences were statistically significant(P<0.01).Point-biserial correla-tion analysis results showed that serum VEGF and TNF-α levels in the combination group were negatively correlated with the therapeutic effect(P<0.05).Conclusion Nivolumab combined with chemotherapy can improve clinical efficacy and has certain safety in the treatment of patients with advanced gastric cancer.The higher the levels of serum VEGF and TNF-α,the more likely the treatment will be ineffective.
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