Relationship between pro-gastrin-releasing peptide,carbohydrate antigen 50,carcinoembryonic antigen and clinical characteristic and prognosis of patients with non-small cell lung cancer
Objective To explore the relationship between pro-gastrin-releasing peptide(ProGRP),carbohydrate anti-gen 50(CA50),carcinoembryonic antigen(CEA)and clinical characteristics and prognosis of patients with non-small cell lung cancer(NSCLC).Method A total of 104 NSCLC patients and 80 healthy subjects were selected as NSCLC group and healthy group,respectively.The serum ProGRP,CA50 and CEA levels in the two groups and NSCLC patients with different clinical characteristics were compared.Followed up for 12 months,the survival of NSCLC patients was record-ed,and Cox regression model was used to analyze the influencing factors for prognosis of NSCLC patients.Result The levels of serum ProGRP,CA50 and CEA in NSCLC group were significantly higher than those in healthy group,and the differences were statistically significant(P<0.01).The levels of serum ProGRP,CA50 and CEA in NSCLC patients with clinical stage Ⅲ-Ⅳ,lymph node metastasis and low differentiation were significantly higher than those in patients with clinical stage Ⅰ-Ⅱ,no lymph node metastasis and medium-high differentiation,and the differences were statistically signif-icant(P<0.01).Multivariate Cox regression analysis showed that lymph node metastasis,ProGRP level≥123.22 pg/ml and CEA level≥47.82 ng/ml were independent risk factors for poor prognosis in NSCLC patients(P<0.05).Conclusion The serum ProGRP,CA50 and CEA levels are higher in NSCLC patients,and lymph node metastasis,ProGRP levels≥123.22 pg/ml and CEA levels≥47.82 ng/ml are independent risk factors for poor prognosis in NSCLC patients.
NETL
NSTL
万方数据
