Application effect of intraoperative neuro navigation microsurgical resection in patients with glioma
Objective To explore the application effect of intraoperative neuro navigation microsurgical resection in patients with glioma.Method A total of 110 glioma patients were divided into navigation group(n=52)and convention-al group(n=58)based on whether intraoperative neuro navigation was applied.Patients in the conventional group under-went conventional microsurgical resection,while patients in the navigation group underwent intraoperative neuro naviga-tion microsurgical resection.The tumor resection status,serum factor indicators[transforming growth factor-β(TGF-β),vascular endothelial growth factor(VEGF),glial fibrillary acidic protein(GFAP)],quality of life[Karnofsky performance status(KPS)score],neurological function[National Institutes of Health stroke scale(NIHSS)score],incidence of compli-cations,and 1-year follow-up survival were compared between the two groups.Result The tumor resection status in the navigation group was better than that in the conventional group,and the difference was statistically significant(P<0.05).Seven days after surgery,the levels of GFAP,VEGF,and TGF-β in both groups were lower than those before surgery,the levels of GFAP,VEGF,and TGF-β in navigation group were lower than those in the conventional group,and the differ-ences were statistically significant(P<0.05).Three months after surgery,the scores of NIHSS in both groups were lower than those before surgery,the scores of KPS were higher than those before surgery,the score of NIHSS in navigation group was lower than that in conventional group,the score of KPS was higher than that in conventional group,and the dif-ferences were statistically significant(P<0.05).There were no statistically significant differences in the total incidence of complications and 1-year survival rate between the two groups(P>0.05).Conclusion The efficacy of intraoperative neu-ro navigation microsurgical resection in the treatment of glioma is significant,which can improve tumor resection,en-hance quality of life and neurological function,and has high safety.
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