Relationship between serum free prostate-specific antigen,C-X-C chemokine ligand 4L1 levels and clinical characteristic and prognosis of patients with prostate cancer undergoing radical prostatectomy
Objective To explore the relationship between serum free prostate-specific antigen(fPSA),C-X-C che-mokine ligand 4L1(CXCL4L1)levels and clinical characteristics and prognosis of patients with prostate cancer undergo-ing radical prostatectomy.Method The medical records of 80 patients with prostate cancer undergoing radical prostatec-tomy were collected,and the levels of fPSA,CXCL4L1 in different clinical characteristics of patients with prostate can-cer undergoing radical prostatectomy were compared.Follow up and record the prognosis,the serum levels of fPSA,CX-CL4L1 in different prognosis of patients with prostate cancer undergoing radical prostatectomy were compared.The clini-cal characteristics and prognostic influencing factors of patients with prostate cancer undergoing radical prostatectomy were analyzed by multivariate Logistic regression.Pearson correlation analysis was used for correlation analysis.Result The serum levels of fPSA,CXCL4L1 in patients with prostate cancer undergoing radical prostatectomy with T staging of T3-4,lymph node metastasis,low to moderate differentiation,and Gleason score≥6 points were significantly higher than those in patients with T staging of T1-2,no lymph node metastasis,high differentiation,and Gleason score<6 points,and the differences were statistically significant(P<0.01).At the end of the follow-up,among 80 patients with prostate cancer undergoing radical prostatectomy,18 cases had poor prognosis and 62 cases had good prognosis.The levels of serum fP-SA and CXCL4L1 in patients with poor prognosis were significantly higher than those in patients with good prognosis,and the differences were statistically significant(P<0.01).Multivariate Logistic regression analysis showed that the levels of serum fPSA and CXCL4L1 elevated were independent risk factors for T staging of T3-4,Gleason score≥6 points,low to moderate differentiation,lymph node metastasis,and poor prognosis in prostate cancer patients undergoing radical prosta-tectomy(P<0.05).Pearson correlation analysis results showed that the serum fPSA level of patients with prostate cancer undergoing radical prostatectomy was positively correlated with the CXCL4L1 level(r=0.314,P<0.01).Conclusion The levels of serum fPSA and CXCL4L1 are related to the clinical characteristics and prognosis of patients with prostate cancer undergoing radical prostatectomy.Elevated levels of both indexes indicate high T staging,lymph node metastasis,low differentiation,high Gleason score,and poor prognosis.
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