Expression of claudin-1 in gallbladder carcinoma and its significance
Objective: To investigate the expression of claudin-1 protein in gallbladder carcinoma and analyze its possible relationship with clinicopathological characters.Methods: The expression of claudin-1 was detected by immunohistochem istry method in47 cases of prinary gallbladder carcinoma, 18 cases of gallbladder adenoma and 15 cases of chronic cholecystitis. The results were analyzed. Results: The positive expression rates of claudin-1 in prinary gallbladder carcinoma, gallbladder adencma and chronic cholecystitis were 89.4%, 27. 8% and 26. 7%, respectively. There was significant difference anong all the groups of gallbladder carcinoma and gallbladder adenoma or gallbladder cholecystitis( P <0. 01) , but no statistics significance between group in gallbladder adenoma and gallbladder cholecystitis( P >0.05). The expression of claudin-1 in gallbladder carcinoma had no significant with patient sage, gender, and histologic type of carcincms(P >0.05). The level of claudin-1 expression was higher in pathological grade( Ⅱ -Ⅲ ) group than that in patiobgical grade Ⅰ group( P < 0.05 ). The level of its expression was significantly higher in Nevin stage(Ⅳ -Ⅴ ) group than that in Nevin stage(Ⅰ - Ⅲ) group(P <0.01) , and higher in lymph node or distantmetastasis group than in non-metestesis group (P <0.05). Conclusions: The expression of claudin-1 in gallbladder carcinoma can provide tips of the biological behavior of gallbtedder carcinoma cells.
NETL
NSTL
万方数据
维普
