Oncocytic papillary renal cell carcinoma:a report of 3 cases and review of the literature
Objective:To investigate the clinicopathological characteristics of the oncocytic papillary renal cell carcinoma(OPRCC). Methods:Three cases of OPRCC were investigated by light microscopy, immunohistochemistry, fluorescence in situ hybridization (FISH),and review of the literature. Results:Among 3 cases,2 cases were male,1 case was female,and their ages were 41,45 and 65 years old,respectively. The renal masses in 3 cases were found by medical examination. The masses in 2 cases located in the low pole of the kidney,and 1 case mass located in the middle and high pole of the kidney,the surrounding boundaries between the renal tissue and tumor was clear,and the long diameter of 3 masses were 3. 0 cm,3. 5 cm and 4. 5 cm,respectively. The cytoplasm of tumor cells were plentiful and eosinophilic,the Fuhrman grades of nuclear were from 2 to 3 grade. Tumor cells arranged in papillary pattern with accumulation of foam cells in the stroma. In 3 cases of tumor cells,vimentin,CD10,AMACR,EMA and CK7 were positive,while TFE3, CD15,CD117,RCC and E-cadherin were negative. FISH test showed that the 7 and 17 chromosomes were amplified in 3 cases of tumor cells. Conclusions:OPRCC is a rarely subtype of renal cell carcinoma,and its immune phenotype and molecular genetics are similar to that of type 1 papillary renal cell carcinoma. The OPRCC should be differentiated with oncocytoma,chromophobe renal cell carcinoma, Xp11. 2 translocation of renal cell carcinoma.
NETL
NSTL
万方数据
维普
