蚌埠医学院学报2024,Vol.49Issue(2) :172-174,181.DOI:10.13898/j.cnki.issn.1000-2200.2024.02.007

影响慢加急性肝衰竭短期预后的危险因素分析

Analysis of risk factors affecting short-term prognosis of acute on chronic liver failure

巴志伟 詹步同 刘传苗
蚌埠医学院学报2024,Vol.49Issue(2) :172-174,181.DOI:10.13898/j.cnki.issn.1000-2200.2024.02.007

影响慢加急性肝衰竭短期预后的危险因素分析

Analysis of risk factors affecting short-term prognosis of acute on chronic liver failure

巴志伟 1詹步同 1刘传苗1
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作者信息

  • 1. 蚌埠医科大学第一附属医院 感染性疾病科,安徽 蚌埠233004
  • 折叠

摘要

目的:分析慢加急性肝衰竭(ACLF)病人的临床数据,探究影响其短期预后的危险因素.方法:收集95例ACLF病人的相关资料,根据入院确诊后30 d预后情况分为死亡组(38例)和生存组(57例),分析影响ACLF病人短期预后的相关危险因素.结果:2组病人入院时白细胞计数、中性粒细胞计数、三酰甘油、载脂蛋白B、凝血酶原时间、国际标准化比值、凝血酶原活动度、胱抑素C(CysC)、并发急性肾损伤(AKI)、终末期肝病模型(MELD)评分差异均有统计学意义(P<0.05~P<0.01);多因素logistic分析提示CysC是影响ACLF病人短期预后的危险因素.结论:CysC较血肌酐更早预警ACLF病人并发AKI可能,且其是影响ACLF病人短期预后的独立危险因素.

Abstract

Objective:To analyze the clinical data of patients with acute on chronic liver failure (ACLF) and determine the risk factors affecting the short-term prognosis. Methods:The relevant data of 95 patients with ACLF were collected and divided into the death group (38 cases) and survival group (57 cases) according to the prognosis 30 days after admission. Then the relevant risk factors affecting the short-term prognosis of ACLF patients were analyzed. Results:There were significant differences in white blood cell count, neutrophil count, triglyceride, apolipoprotein B, prothrombin time, international normalized ratio, prothrombin activity, cystatin C ( CysC) ,complication with acute kidney injury and the score of model for end-stage liver disease ( MELD) between the two groups at admission (P<0. 05 to P <0. 01). Multivariate logistic analysis suggested that CysC was a risk factor for short-term prognosis of patients with ACLF. Conclusions:CysC is an earlier warning factor for ACLF patients complicated with AKI than Cr, which is an independent risk factor for the short-term prognosis of ACLF patients.

关键词

慢加急性肝衰竭/胱抑素C/预后/危险因素

Key words

acute-on-chronic liver failure/cystatin C/prognosis/risk factors

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基金项目

安徽省高等学校自然科学研究重点项目(KJ2017A247)

出版年

2024
蚌埠医学院学报
蚌埠医学院

蚌埠医学院学报

CSTPCD
影响因子:0.917
ISSN:1000-2200
参考文献量16
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