Value of high-resolution magnetic resonance imaging parameters with serum MMP9 and hs-CRP to predict the occurrence of acute stroke in patients with middle cerebral artery atherosclerotic stenosis
Value of high-resolution magnetic resonance imaging parameters with serum MMP9 and hs-CRP to predict the occurrence of acute stroke in patients with middle cerebral artery atherosclerotic stenosis
Objective:To detect the expression levels of serum matrix metalloproteinase-9 ( MMP9 ) and high-sensitivity C reactive protein ( hs-CRP) in patients with middle cerebral artery atherosclerotic stenosis and analyze the value of MMP9 and hs-CRP combined with high-resolution magnetic resonance imaging ( HRMRI) parameters in predicting the occurrence of acute stroke. Methods:A total of 183 patients with middle cerebral artery atherosclerotic stenosis were selected and divided into the acute stroke group (89 cases) and non-acute stroke group ( 94 cases ) according to whether acute stroke occurred during hospitalization. Predictive values of stenosis degree,serum MMP9 and hs-CRP levels in patients with middle cerebral artery atherosclerotic stenosis were analyzed. Results:Vulnerable plaque,degree of stenosis,Essen stroke risk score (ESRS) and levels of MMP9,hs-CRP in the acute stroke group were higher than those in non-acute stroke group (P<0. 05). The area under curve (AUC) of degree of stenosis and the levels of MMP9 and hs-CRP in the predictive of acute stroke in patients with atherosclerotic stenosis were 0. 886,0. 857 and 0. 634,respectively,and AUC of their combination was 0. 923. Conclusions:Serum MMP9 and hs-CRP combined with HRMRI parameters can greatly improve the accuracy of prediction in acute stroke.
关键词
大脑中动脉粥样硬化性狭窄/急性卒中/高分辨率磁共振/超敏C反应蛋白/基质金属蛋白酶9
Key words
middle cerebral artery atherosclerotic stenosis/acute stroke/high-resolution magnetic resonance imaging/high-sensitivity C reactive protein/matrix metalloproteinase 9
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