Objective:To investigate the predictive value of interleukin-10 (IL-10) and catalase (CAT) in post-stroke depression ( PSD) in patients with acute ischemic stroke. Methods:Serum IL-10 and CAT levels in 151 patients with acute ischemic stroke within 24 h of hospital admission were measured. Depressive symptoms were assessed using the 17-item Hamilton depression scale ( HAMD-17),and PSD was defined as a HAMD score ≥8. Results:At 1-month follow-up after stroke,51 (33. 8％) patients were diagnosed with PSD. Compared with non-PSD patients, the PSD group had higher NIHSS scores at admission and discharge, larger cerebral infarction volume,lower BI score,higher mRS score,and lower serum CAT and IL-10 levels (P<0. 05). After adjusting for potential confounders (P<0. 05 in univariate logistic regression analysis),IL-10 (OR=0. 615,95％CI:0. 410 -0. 923) and CAT (OR =0. 757,95％CI:0. 652-0. 914) were independent predictors of PSD. IL-10 levels (r=0. 394,P<0. 01) and CAT levels (r=0. 306, P<0. 01) were negatively correlated with HAMD scores in PSD patients. ROC analysis showed that the cutoff point for serum IL-10 levels was 2. 06 pg/mL,and the AUC for predicting PSD was 0. 739. Meanwhile,the cutoff point for the CAT level was 1. 07 U/L,and the AUC for predicting PSD was 0. 630. Patients with lower IL-10 levels ( <2. 06 pg/mL) were more likely to develop PSD than their counterparts (≥2.06 pg/mL) (OR =9.750,95％CI =2. 671 -35. 534,P <0. 01). Meanwhile,patients with lower CAT levels ( <1. 07 U/L) were more likely to develop PSD than their counterparts (≥1. 07 U/L) (OR=5. 052,95％CI=1. 256-20. 322,P<0. 05). Conclusions:Serum IL-10 and CAT can be used as independent protective predictors of PSD in patients with acute ischemic stroke. Patients with low levels of IL-10 and CAT are more likely to develop PSD 1 month after stroke.
维普
万方数据