蚌埠医学院学报2024，Vol.49Issue(2) ：230-233.DOI:10.13898/j.cnki.issn.1000-2200.2024.02.020

血清Kisspeptin、Betatrophin水平与妊娠期糖尿病病人胰岛素抵抗的相关性分析

Correlation between serum Kisspeptin,Betatrophin levels and insulin resistance in gestational diabetes mellitus patients

张艳明 赵晔 胡月玲 史慧芳
蚌埠医学院学报2024，Vol.49Issue(2) ：230-233.DOI:10.13898/j.cnki.issn.1000-2200.2024.02.020
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  • 维普
  • 万方数据

血清Kisspeptin、Betatrophin水平与妊娠期糖尿病病人胰岛素抵抗的相关性分析

Correlation between serum Kisspeptin,Betatrophin levels and insulin resistance in gestational diabetes mellitus patients

张艳明 1赵晔 1胡月玲 1史慧芳1
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作者信息

  • 1. 邢台医学高等专科学校第二附属医院 产科,河北 邢台054000
  • 折叠

摘要

目的:探讨血清人吻素-1(Kisspeptin)、促代谢因子(Betatrophin)水平与妊娠期糖尿病(GDM)病人胰岛素抵抗的相关性.方法:选择86例GDM病人(GDM组)和60例正常妊娠孕妇(NGT组),均检测血清Kisspeptin、Betatrophin水平,分析其与GDM发生胰岛素抵抗的相关性.结果:GDM组空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、糖化血红蛋白(HbAlc)、总胆固醇(TC)、三酰甘油(TG)、Kisspeptin、Betatrophin水平高于NGT组(P<0.01),Pearson相关性分析血清Kisspeptin、Betatrophin水平与TC、TG、PFG、FINS、HOMA-IR呈正相关关系(r=0.367～0.576,P<0.01),Kisspeptin与Betatrophin之间呈正相关关系(r=0.326,P<0.05).多重线性回归分析Kisspeptin(B=0.671)、Betatrophin(B=0.886)均与GDM病人HOMA-IR独立相关(P<0.05～P<0.01).结论:GDM病人血清Kisspeptin、Betatrophin水平明显升高,Kisspeptin、Betatrophin水平均与GDM病人胰岛素抵抗存在正线性相关关系.

Abstract

Objective:To investigate the correlation between serum Kisspeptin,Betatrophin levels,insulin resistance in patients with gestational diabetes mellitus ( GDM ) . Methods:A total of 86 GDM patients ( GDM group ) and 60 normal pregnant women ( NGT group) were selected. Serum Kisspeptin and Betatrophin levels were detected. The correlation between serum Kisspeptin, Betatrophin levels and insulin resistance in GDM was analyzed. Results:The levels of fasting plasma glucose (FPG),fasting insulin (FINS), homeostasis model assessment-insulin resistance (HOMA-IR),hemoglobin A1c (HbA1c),total cholesterol (TC),triglycerides (TG), Kisspeptin and Betatrophin in the GDM group were higher than those in the NGT group (P <0. 01). Pearson correlation analysis showed that serum Kisspeptin and Betatrophin levels were positively correlated with TC,TG,PFG,FINS and HOMA-IR ( r=0. 367-0. 576,P<0. 01),and Kisspeptin was positively correlated with Betatrophin (r=0. 326,P<0. 05). Multiple linear regression analysis results showed that Kisspeptin (B=0. 671) and Betatrophin (B=0. 886) were independently correlated with HOMA-IR in patients with GDM (P<0. 05 to P<0. 01). Conclusions:Serum Kisspeptin and Betatrophin levels are significantly increased in GDM patients, and there is a positive linear correlation between Kisspeptin,Betatrophin levels and insulin resistance in GDM patients.

关键词

妊娠期糖尿病/人吻素-1/促代谢因子/胰岛素抵抗/糖脂代谢紊乱

Key words

gestational diabetes mellitus/Kisspeptin/Betatrophin/insulin resistance/disorder of glucose and lipid metabolism

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基金项目

河北省中医药局中医药类科研计划(2020)(2020561)

出版年

2024
蚌埠医学院学报
蚌埠医学院

蚌埠医学院学报

CSTPCD
影响因子：0.917
ISSN：1000-2200
参考文献量17
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