摘要
目的:探讨简易头部降温联合神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的临床疗效.方法:选取HIE患儿 100例,按照随机数字表法分为对照组和观察组,各50 例.对照组给予神经节苷脂治疗,观察组给予简易头部降温联合神经节苷脂治疗.比较2 组患儿临床表现改善时间、治疗前后相关血液学指标和新生儿神经行为评分(NBNA)及临床疗效、不良反应发生情况.结果:观察组患儿惊厥、意识障碍、瞳孔改变、肌张力低下、胃肠功能紊乱改善时间均明显少于对照组(P<0.01).治疗后2 组患儿NSE、IL-6、CK、CK-MB均明显低于治疗前(P<0.01),血清钙、NBNA评分均明显高于治疗前(P<0.01),且观察组患儿各指标均明显优于对照组(P<0.01).观察组患儿治疗总有效率为 82.00%(41/50),高于对照组的 62.00%(31/50)(P<0.05),2 组患儿均无明显不良反应.结论:简易头部降温联合神经节苷脂治疗HIE能改善患儿临床症状、血液检查指标和NBNA评分,临床疗效明确且优于单一使用神经节苷脂治疗.
Abstract
Objective:To investigate the clinical efficacy of simple head cooling combined with ganglioside in neonates with hypoxic-ischemic encephalopathy(HIE).Methods:A total of 100 neonates with HIE were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 50 cases in each group.The control group was treated with ganglioside,and the observation group was treated with simple head cooling combined with ganglioside.The clinical performance improvement time,level of hematological indexes before and after treatment,neonatal neurobehavioral score(NBNA),clinical efficacy,and adverse reactions were compared between the two groups.Results:The improvement time of convulsions,disturbance of consciousness,pupil changes,hypotonia,and gastrointestinal dysfunction in the observation group were significantly lower than those in the control group(P<0.01).After treatment,the NSE,IL-6,CK,and CK-MB of the two groups were significantly lower than those before treatment(P<0.01),the serum calcium and NBNA scores were significantly higher than those before treatment(P<0.01),and all indicators of children in the observation group were significantly higher than those in the control group(P<0.01).The total effective rate of the observation group(82.00%,41/50)was higher than that of the control group(62.00%,31/50)(P<0.05).There were no obvious adverse reactions in the two groups.Conclusions:The simple head cooling combined with ganglioside in the treatment of HIE can significantly improve the clinical symptoms,hematological examination index levels,and NBNA score.The clinical efficacy is clear and superior to that of ganglioside alone.
基金项目
安徽省自然科学基金面上项目(1808085MH308)
安徽省合肥市科技局"借转补"项目(J2018Y06)
安徽医科大学校科研基金项目(2019xkj178)
NETL
NSTL
维普
万方数据