Objective:To investigate the differences in impulsivity between methamphetamine (MA)-dependent and healthy populations,as well as to explore the effects of high-frequency 10 Hz mode repetitive transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS) on impulsivity and craving in MA-dependent individuals.Methods:Seventy-five MA-dependent subjects undergoing withdrawal treatment in a drug rehabilitation facility in Anhui province were divided into three groups using a random number table method:the sham stimulation group,the rTMS group and the iTBS group.All subjects received the Barratt impulsiveness scale (BIS-11) and the VAS scale before and after transcranial magnetic therapy.Fifty healthy adult males matched to the general profile of MA-dependent individuals were recruited from the community and served as healthy controls.Results:The motor impulsivity and total score of the MA-dependent group were higher than those of the healthy control group (P<0.01).After 4 weeks of treatment,both the rTMS and iTBS groups showed a decrease in craving,motor impulsivity,and total score scores (P<0.05 to P<0.01),There was no statistically significant difference in scores between the sham stimulation group before and after treatment (P>0.05),The inter group comparison found that the motor impulsivity and total score of the rTMS group after treatment were lower than those of the sham stimulation group (P<0.05),while the motor impulsivity,cognitive impulsivity,unplanned impulsivity,and total score of the iTBS group after treatment were lower than those of the sham stimulation group (P<0.05 to P<0.01);There was no statistically significant difference in craving among the three groups after treatment (P>0.05).The reduction rates of motor,cognitive,and total impulse scores in the iTBS group were significantly higher than those in the sham stimulation group (P<0.01),while the reduction rates of motor and total impulse scores in the rTMS group were higher than those in the sham stimulation group (P<0.05 to P<0.01).There was no statistically significant difference in the change in craving among the three groups (P>0.05).Conclusions:MA-dependent individuals have high levels of impulsivity.Both iTBS and 10 Hz rTMS help to reduce impulsivity and craving in dependent individuals,and the treatment effects of both modalities were comparable.
关键词
甲基苯丙胺依赖/重复经颅磁刺激/冲动性/渴求
Key words
methamphetamine dependance/transcranial magnetic stimulation/impulsivity/craving
维普
万方数据