蚌埠医学院学报2024，Vol.49Issue(5) ：585-589.DOI:10.13898/j.cnki.issn.1000-2200.2024.05.006

急性冠脉综合征病人sTREM-1和hs-CRP水平与冠脉血管病变程度及短期临床预后相关性

Study on the correlation of the serum levels of sTREM-1 and hs-CRP with degree of coronary vascular disease and short-term clinical prognosis in patients with acute coronary syndrome

范新俊 赵胜 戎李 高彦琳 孙志勇 李天宇 成威 LIU Dinghong
蚌埠医学院学报2024，Vol.49Issue(5) ：585-589.DOI:10.13898/j.cnki.issn.1000-2200.2024.05.006
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  • 万方数据

急性冠脉综合征病人sTREM-1和hs-CRP水平与冠脉血管病变程度及短期临床预后相关性

Study on the correlation of the serum levels of sTREM-1 and hs-CRP with degree of coronary vascular disease and short-term clinical prognosis in patients with acute coronary syndrome

范新俊 1赵胜 1戎李 1高彦琳 1孙志勇 1李天宇 1成威 1LIU Dinghong2
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作者信息

  • 1. 安徽省第二人民医院 心内科,安徽 合肥230000
  • 2. Department of Cardiology,The Second People's Hospital of Anhui,Hefei Anhui 230000,China
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摘要

目的:观察血清髓系细胞触发受体1(sTREM-1)和超敏C反应蛋白(hs-CRP)与冠脉血管病变程度及临床预后的相关性.方法:入选200例行冠状动脉造影病人,根据病史、相关检查及冠脉造影结果分为不稳定型心绞痛组(UAP组,共135例)、急性心肌梗死组(AMI组,25例)和非冠心病组(对照组,共40例).检测病人血清sTREM-1和hs-CRP水平,并对所有病人进行平均6个月的随访,评估2组病人主要心脏不良事件(MACE)的发生情况.结果:AMI组、UAP组病人血清sTREM-1和hs-CRP水平高于对照组(P<0.05),在三支和重度病变组(Gensini评分>48分)中血清sTREM-1和hs-CRP高于单双支及轻中度病变组(P<0.05).随访平均6个月后发现MACE组病人血清sTREM-1和hs-CRP水平高于非MACE组(P<0.05);二元logstic回归分析显示,hs-CRP、sTREM-1和Gensini评分为ACS病人MACE事件的危险因素(P<0.05).ROC曲线结果示血清sTREM-1和血清hs-CRP预测ACS病人MACE事件发生风险的最佳截断值分别为0.33 mg/L和6.30 mg/L,且两者联合可提升诊断的特异度(P<0.05).结论:ACS病人具有较高的血清sTREM-1和hs-CRP水平;ACS病人血清sTREM-1和hs-CRP水平与冠脉血管病变支数和病变严重程度呈正相关关系;血清sTREM-1和hs-CRP与ACS病人MACE呈正相关关系且两者联合诊断可提升MACE事件预测的特异度.

Abstract

Objective:To investigate the correlation of the serum levels of myeloid cell trigger receptor 1 ( sTREM-1 ) and hypersensitive C-reactive protein(hs-CRP) with degree of coronary vascular disease and clinical prognosis. Methods:Two hundred patients with coronary angiography were selected,and divided into the unstable angina group( UAP group,135 cases),acute myocardial infarction group (AMI group,25 cases) and non-coronary heart disease group(control group,40 cases) according to their medical history,related examinations and coronary angiography results. The serum levels of sTREM-1 and hs-CRP in all cases were measured,and all patients were followed up for a mean of 6 months to assess the occurrence of major adverse cardiac events(MACE). Results:The serum levels of sTREM-1 and hs-CRP levels in the AMI group and UAP group were significantly higher than those in control group (P<0. 05),and the serum sTREM-1 and hs-CRP levels in triple branches and severe groups(Gensini score>48 points) were significantly higher than those in single,double branches and mild,moderate disease groups(P<0. 05). The serum sTREM-1 and hs-CRP levels in MACE group were higher than those in non-MACE group after 6 months of follow-up(P<0. 05). The results of binary logistic regression analysis showed that the hs-CRP,sTREM-1 and Gensini score were the risk factors of MACE events in ACS patients (P<0. 05). The results of ROC curve showed that the optimal cut-off values of serum sTREM-1 and hs-CRP in predicting the risk of MACE events in ACS patients were 0. 33 mg/L and 6. 30 mg/L,respectively,and the combination of sTREM-1 and hs-CRP could improve the diagnostic specificity(P<0. 05). Conclusions:Patients with ACS have higher serum sTREM-1 and hs-CRP levels. The serum levels of sTREM-1 and hs-CRP in ACS patients are positively correlated with the number and severity of coronary artery lesions. The serum levels of sTREM-1 and hs-CRP are positively correlated with MACE in ACS patients,and the combination of sTREM-1 and hs-CRP can improve the specificity of MACE event prediction.

关键词

急性冠脉综合征/超敏C-反应蛋白/血清髓系细胞触发受体1

Key words

acute coronary syndrome/hypersensitive C-reactive protein/myeloid cell trigger receptor 1

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基金项目

安徽省临床重点专科建设项目()

安徽医科大学校科研基金(2021xkj117)

出版年

2024
蚌埠医学院学报
蚌埠医学院

蚌埠医学院学报

CSTPCD
影响因子：0.917
ISSN：1000-2200
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