Correlation analysis of the serum anti-Sa and anti-CCP levels with osteoarticular injury and systemic inflammatory response in patients with rheumatoid arthritis complicated with osteoarthritis
Correlation analysis of the serum anti-Sa and anti-CCP levels with osteoarticular injury and systemic inflammatory response in patients with rheumatoid arthritis complicated with osteoarthritis
Objective:To analyze the correlations between the serum levels of anti-Sa and anti-CCP antibody and osteoarticular injury and systemic inflammatory response in patients with rheumatoid arthritis ( RA ) . Methods:One hundred and eight RA patients with osteoarticular injury were divided into the high anti-SA group,low anti-SA group,high anti-CCP group and low anti-CCP group according to the serum levels of anti-Sa and anti-CCP. The differences of WOMAC osteoarthritis index,lysholms knee function score,serum levels of interleukin(IL)-1β,IL-6,IL-27 and tumor necrosis factor α(TNF-α) were compared among all groups. The Pearson test was used to evaluate the correlation of relevant indicators. Results:The WOMAC osteoarthritis indexes in high anti-Sa group and high anti-CCP group were significantly higher than that in low anti-Sa group(P<0. 01),and the lysholms knee function scores in high anti-Sa group and high anti-CCP group were significantly lower than that in low anti-Sa group(P<0. 01). The serum levels of IL-1β,IL-6,IL-27 and TNF-α in the high anti-Sa group and high anti-CCP group were significantly higher than those in low anti-CCP group(P<0. 01) . The serum anti-Sa and anti-CCP antibody levels in RA patients were positively correlated with the severity of osteoarticular injury and systemic inflammatory response (P<0. 05 to P<0. 01),and negatively correlated with the lysholms knee function score(P<0. 01). Conclusions:The serum levels of anti-Sa and anti-CCP antibodies in patients with RA significantly increase,which is correlated with the joint injury and systemic inflammatory response,and can be used as a reference index in the clinical judgment of disease activity and osteoarticular injury.
维普
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