Objective:To investigate the effects of the intraoperative infusion of low-dose esketamine on postoperative fatigue syndrome(POFS)in patients treated with thyroidectomy.Methods:A total of 100 patients treated with thyroidectomy under general anesthesia were randomly divided into the esketamine group(LKET group)and0.9%sodium chloride injection control group(control group)(50 cases in each group).After anesthesia induction,the 0.5 mg/kg esketamine was administered intravenously,followed by 4 μg·kg-1·min-1 continuous pumping in the LKET group.The control group was given equal volume 0.9%sodium chloride injection.The intraoperative sufentanil dosage,mean arterial pressure,postoperative extubation time and recovery time,Ramsay score and postoperative adverse reactions in two groups were recorded.The fatigue scale(FS-14),Pittsburgh sleep quality index(PSQI)and VAS scores in two groups were recorded after 1,3 and 5 days of operation,and the incidence rate of POFS was calculated.Results:Compared with the control group,the intraoperative sufentanil dosage in the LKET group was less(P＜0.01),the Ramsay score was higher(P＜0.01),and there was no statistical significance in the incidence rate of postoperative adverse reactions between two groups(P＞0.05).The scores of FS-14,VAS and PSQI in the LKET group at 1,3 and 7 days after surgery were significantly lower than those in control group(P＜0.01),and the incidence of POFS at 1 and 3 days after surgery was significantly lower(P＜0.05 and P＜0.01).Conclusions:The low-dose esketamine under general anesthesia can improve the postoperative fatigue and sleep quality,and reduce the incidence of POFS after thyroidectomy.
维普
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