Objective:To investigate the clinical efficacy and safety of anti-vascular endothelial growth factor (VEGF) combined with Ahmed glaucoma drainage valve(AGV) implantation in the treatment of neovascular glaucoma(NVG).Methods:The clinical data of 47 patients with NVG were retrospectively analyzed.The patients were treated with Ahmed glaucoma drainage valve(AGV) implantation[AGV group,25 cases (25 eyes)]and trabeculectomy[trabecular group,22 cases(22 eyes)].Two groups were injected with intravitreal anti-VEGF drugs before surgery,the panretinal photocoagulation was completed after surgery,and all cases were regularly followed up within 1 year.The best corrected visual acuity improvement,intraocular pressure(IOP) before and after surgery,use of anti-glaucoma drugs,postoperative complications and operation success rate were compared between two groups.Results:After anti-VEGF treatment,the neovascularization of iris surface in two groups showed regression to different degrees,and the IOP in two groups was lower than that before surgery(P<0.05).At each time-point of operation,the IOP in two groups was lower than that before surgery and after anti-VEGF treatment (P<0.05).There was no statistical significance in the IOP between two groups at each time-point(P>0.05).There was no statistical significance in the best corrected visual acuity between two groups after operation(P>0.05).Compared with before operation,the types of anti-glaucoma drugs use after operation reduced significantly in two groups(P<0.01).There was no statistical significance in the incidence of postoperative complications between two groups(P>0.05).The operative success rate in the AGV group was higher than that in trabecular group (P<0.05).Conclusions:Intravitreal injection of anti-VEGF agents combined with AGV implantation is effective and safe in the treatment of neovascular glaucoma.
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