摘要
目的:探讨血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、PGⅠ/PGⅡ比值(PGR)、胃泌素-17(G-17)与幽门螺旋杆菌(Hp)抗体分型检测在慢性萎缩性胃炎(CAG)诊断中的应用价值.方法:选取170例慢性胃炎病人,其中CAG组79例,慢性非萎缩性胃炎(CNAG)91例,比较2组指标的变化.结果:170例病人中Hp阳性92例,阳性率54.12％.与CNAG组比较,CAG组Hp抗体阳性率、Ⅰ型Hp感染阳性率、PGⅡ和G17水平均明显升高(P<0.05～P<0.01),PGR水平降低(P<0.01).Ⅰ型Hp阳性组与Ⅱ型Hp阳性组相比,PGⅡ和G17的表达水平升高(P<0.05),PGR水平降低(P<0.05).PGⅠ、PGⅡ、PGR、G17和Hp抗体分型的AUC分别为0.548、0.606、0.361、0.660、0.589;联合检测的AUC为0.690.结论:PGⅡ、PGR、G17水平变化及Hp抗体分型可作为萎缩性胃炎筛查指标,联合检测可为临床诊疗提供更可靠的实验室依据.
Abstract
Objective:To investigate the value of serum pepsinogen Ⅰ(PGⅠ),pepsinogen Ⅱ(PGⅡ),PGⅠ/PGⅡ ratio(PGR),gastrin-17(G17) and Helicobacter pylori(Hp) antibody typing in the diagnosis of chronic atrophic gastritis(CAG).Methods:A total of 170 patients with chronic gastritis were divided into the CAG group(79 cases) and chronic non-atrophic gastritis(CNAG) group(91 cases).The changes of indicators were compared between two groups.Results:Ninety-two cases(54.12％) of 170 patients were positive for Hp.Compared with the control group,the Hp antibody positive rate,infection positive rate of type Ⅰ Hp,PGⅡ and G17 levels significantly increased(P<0.05 to P<0.01),while the PGR level decreased in the CAG group(P<0.01).Compared with type Ⅱ Hp positive group,the expression levels of PGⅡ and G17 increased,while the PGR level decreased in the type Ⅰ Hp positive group (P<0.05).The AUC of PGⅠ,PGⅡ,PGR,G17 and Hp antibody typing were 0.548,0.606,0.361,0.660 and 0.589,respectively.The AUC of combined detection was 0.690.Conclusions:The level changes of PGⅡ,PGR,G17 and Hp antibody type can be used as the screening indicators of CAG,and the combined detection can provide a more reliable laboratory basis for clinical diagnosis and treatment.
基金项目
天然药物活性组分与药效国家重点实验室开放研究课题(SKLNMKF202007)
维普
万方数据