Objective:To investigate the correlation between neonatal birth indicators and bone age(BA)development in children.Methods:A total of 258 neonates were selected as the study subjects,and 60 neonates participated in the subsequent physical examination at the age of 4.All subjects underwent X-rays of the left hand to calculate the bone age progress index[ratio of BA to chronological age(CA)(BA/CA)].The association between growth variables at birth and BA/CA was evaluated using the Pearson correlation analysis.Linear regression was used to analyze the effects of growth variables on the BA/CA at 4 years of age.Results:The 42.9％of the lowest birth weight group remained at the lowest weight group after 4 years.About 78.6％of those with the lowest birth weight were in the highest conditioned weight gain group at age 4,and 68.8％of those with the highest birth weight were in the lowest conditioned weight gain group at age 4.The BA/CA was positively correlated with birth weight(r=0.412,P＜0.01).The results of multiple linear regression analysis showed that BA/CA increased with birth weight.After adjusting the sex,gestational age and height at age 4,the BA/CA increased with birth weight and conditional body mass(P＜0.05).Conclusions:Neonate birth weight and subsequent growth acceleration are associated with an increased risk of early BA in young children.
维普
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