Research Advances in the Epidemic Characteristics and Influencing Factors of Human Norovirus Infection-induced Acute Gastroenteritis
Human norovirus(HuNoV)is a non-enveloped,positive-sense,single-stranded RNA virus belonging to the NoV genus of the Caliciviridae family.HuNoV demonstrates rapid mutation and recombination,along with a heightened infectivity and pathogenicity at low concentrations,thereby making it a significant etiological agent of acute gastrointestinal illness across all age groups worldwide.Children aged ≤5 years and individuals＞65 years are particularly susceptible to NoV-associated gastroenteritis(AGE),which can lead to electrolyte imbalances or death due to dehydration.Often,HuNoV also cause AGE outbreaks in semi-closed or enclosed settings with high crowd density.The emergence of novel variants and/or genotypes may lead to a substantial increase outbreaks events or pandemics.Consequently,HuNoV AGE poses a considerable burden and threatens public health globally.We conducted a comprehensive review of the progress of global epidemiological research on HuNoV AGE and the key factors influencing the epidemic characteristics of HuNoV AGE,including host,virus,and environment.This review aims to provide valuable insights for enhancing prevention-and-control strategies against HuNoV AGE.
Human norovirusAcute gastroenteritisEpidemiological characteristicsInfluencing factors
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