Dynamic Changes in Cytokine Levels in Young People Infected with the Omicron Variant of SARS-CoV-2
We wished to evaluate the dynamic changes in cytokine immune profiles before as well as 7,14,and 21 days after infection with the severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)variants Omicron BA.5 and BF.7 during the epidemic period in Beijing(China)from December 2022 to March 2023 to prevent excessive inflammatory reaction and serious diseases.Levels of 12 cytokines were measured in the serum samples of 15 study participants before as well as 7,14,and 21 days after SARS-CoV-2 infection by Cytek Aurora flow cytometry(Cytek,USA)to evaluate the cytokine response against SARS-CoV-2 infection.A longitudinal study of cytokine immune profiles after SARS-CoV-2 infection was successfully constructed.After SARS-CoV-2 infection,the levels of all cytokines showed obvious dynamic changes compared with those before infection.Levels of IL-6,IL-17A,and MIP-1β increased significantly 7 days after infection,then decreased on days 14 and 21.Compared with before infection,levels of IL-2,IL-4,IL-22,and IL-9 increased significantly after SARS-CoV-2 infection and remained at a high level until 21 days.Compared with the rapid increase in the IL-6 level after infection,levels of TNF-α,IL-10,IFN-γ,IL-8,and RANTES increased slowly after infection,reaching the highest expression on days 14 or 21,which indicated their timely regulation of them along the during disease progression.Levels of pro-inflammatory and anti-inflammatory cytokines maintained the correct balance after SARS-CoV-2 infection to ensure that infection did not worsen.SARS-CoV-2 can be cleared in a short time,but the cytokine reaction lasts for more than 21 days.
COVID-19 infectionCytokines immune profilesSARS-CoV-2-OmicronLongitudinal cohort study
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NSTL
万方数据
