自组装颗粒化新冠疫苗研究进展
Research Advances on COVID-19 Self-Assembled Nanoparticle Vaccine
汪晨 1尹一凡 1林敏 1赵小蒙 1郑子峥 1夏宁邵 1张军1
作者信息
- 1. 厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门大学公共卫生学院,厦门 361102
- 折叠
摘要
自组装纳米颗粒作为抗原展示平台可以有效增强抗原的免疫效果和稳定性,是有前景的疫苗技术.新冠疫情加速了颗粒化新冠疫苗的发展,目前已有一些应用纳米颗粒的新冠疫苗处于不同的临床试验阶段.本文介绍了几种自组装颗粒化抗原展示平台在新冠疫苗中的应用,并对其免疫机制和研究进展进行了综述.
Abstract
Self-assembled nanoparticles as an antigen display platform can effectively enhance the immune effect and stability of antigens,which is a promising vaccine technology.Covid-19 epidemic has accelerated the development of particulate COVID-19 vaccines,and there are already some COVID-19 vaccines using nanoparticles in various stages of clinical trials.In this paper,the application of several self-assembled particulate antigen display platforms in the COVID-19 vaccine development is introduced,and the immune mechanisms and research progresses are reviewed.
关键词
新冠病毒/颗粒化抗原展示平台/自组装/疫苗免疫Key words
COVID-19/Particle-based antigen display platform/Self-assembly/Vaccine immunization引用本文复制引用
基金项目
中央高校基本科研业务费专项(20720220006)
中央高校基本科研业务费专项(20720220006)
出版年
2024
NETL
NSTL
万方数据