病毒性疾病基因修饰小鼠模型的研究进展
Research Advances in Genetically Modified Mouse Models of Viral Diseases
吴海婷 1范胜涛 1张才星 1李牧遥 2张艺薇 1黄璋琼1
作者信息
- 1. 北京协和医学院中国医学科学院医学生物学研究所,昆明 650118
- 2. 澳门科技大学,中国澳门 999078
- 折叠
摘要
随着腺相关病毒、慢病毒载体转染及靶向核酸酶等基因修饰技术迅速发展,其被广泛应用于构建病毒性疾病基因修饰小鼠模型,这对于研究病毒的结构、功能及致病机制具有重要的价值.本文就近年来构建的基因修饰小鼠病毒感染模型进行梳理,讨论基因修饰技术在多种病毒性疾病小鼠模型中的研究进展,分析这些模型对在病毒性疾病的预防和治疗中的应用前景,以期为病毒性疾病相关的治疗药物和疫苗研究提供参考.
Abstract
With the rapid development of gene modification technologies such as adeno-associated virus,lentiviral vector transfection and targeted nucleases,the establishment and application of gene modified mouse models are becoming more and more widespread and have become one of the emerging and effective animal experimental models.The genetically modified mouse models of viral infectious diseases established with these technologies are of great value for studying the structure,function and pathogenesis of viruses.In this paper,we reviewed the progress of genetically modified mouse models of viral infections in recent years,analyzed and discussed the research progress of genetic modification techniques in various mouse models of viral infectious diseases,and looked forward to the prospects of these techniques for promoting the prevention and treatment of viral infectious diseases,in order to provide references for the research of viral infectious disease-related drugs and vaccines and the preparation of related animal models.
关键词
基因修饰/病毒性疾病/小鼠模型Key words
Gene modification/Viral infectious disease/Mouse model引用本文复制引用
基金项目
云南省科技厅科技项目(202105AD160018)
中国医科院医学与健康科技创新工程项目(2021-12M-1-043)
国家自然科学基金联合基金(U2022214)
出版年
2024
NETL
NSTL
万方数据