Research Advances in Genetically Modified Mouse Models of Viral Diseases
With the rapid development of gene modification technologies such as adeno-associated virus,lentiviral vector transfection and targeted nucleases,the establishment and application of gene modified mouse models are becoming more and more widespread and have become one of the emerging and effective animal experimental models.The genetically modified mouse models of viral infectious diseases established with these technologies are of great value for studying the structure,function and pathogenesis of viruses.In this paper,we reviewed the progress of genetically modified mouse models of viral infections in recent years,analyzed and discussed the research progress of genetic modification techniques in various mouse models of viral infectious diseases,and looked forward to the prospects of these techniques for promoting the prevention and treatment of viral infectious diseases,in order to provide references for the research of viral infectious disease-related drugs and vaccines and the preparation of related animal models.
Gene modificationViral infectious diseaseMouse model
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