Methods Employed by DNA and RNA Viruses to Evade the Antiviral Immune Response Mediated by the cGAS-STING Pathway
The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway is very important in the realm of innate immunity.Upon viral infection,the host employs this pathway to trigger the expression of interferon and interferon-stimulated genes,thereby manifesting potent antiviral effects.Nonetheless,viruses have evolved diverse strategies to counteract the antiviral immune response to ensure their survival and replication.Different viruses exhibit distinct influences on specific targets of the cGAS-STING signaling pathway.Furthermore,different viral proteins of the same virus engage varying mechanisms to manipulate the functionality of the cGAS-STING signaling pathway.We provide a comprehensive overview of the various methods and tactics employed by DNA and RNA viruses to evade the antiviral immune response mediated by the cGAS-STING pathway.This review provides a reference for study of the pathogenic mechanism of viral infection as well as the development of vaccines and drugs.
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