Application Value of Human Papillomavirus Genotyping Combined with TCT in Early Screening for Cervical Cancer
We wished to investigate human papillomavirus(HPV)genotyping combined with the Thin-prep cytologic test(TCT)to ascertain the application value of TCT in early screening for cervical cancer(CC).A total of 176 patients who underwent CC screening in the gynecological outpatient department of our hospital from March 2020 to September 2023 were enrolled.All patients underwent HPV genotyping detection,TCT detection,and colposcopic cervical histopathology.Pathological test results were used as the"gold standard"to analyze the diagnostic coincidence of HPV genotyping,TCT detection,as well as the combined detection of cervical lesions and CC.The diagnostic value of the two tests alone and combined detection in early screening for CC was evaluated using the area under the receiver operating characteristics(ROC)curve(AUC).Forty-seven(26.70％)cases of HPV infection were detected in 176 patients who underwent CC screening.The top-five subtypes of HPV infection were HPV 16,HPV 58,HPV52,HPV 18 and HPV 11.The coincidence of HPV gene detection was 76.92％(10/13)compared with pathological detection.The diagnostic coincidence of TCT for cervical precancerous lesions and CC was 53.85％(7/13).These results showed that the diagnostic coincidence of TCT alone and HPV gene detection alone was lower than that of combined detection using HPV and TCT.The difference between the diagnostic coincidence of TCT and combined detection was significant(P＜0.05).The diagnostic sensitivity of combined detection of HPV and TCT was higher than that of single detection,and the diagnostic sensitivity of combined detection was more significant than that of TCT detection(P＜0.05).The AUC of the combined test was higher than that of the HPV test alone and TCT test alone(P＜0.05).Overall,we showed that the diagnostic success of HPV genotyping combined with TCT detection was consistent with that of pathology detection in early screening for CC.The diagnostic coincidence of combined detection was higher than that of single detection.Combined detection could improve the diagnostic efficiency of cervical lesions.
Human papillomavirus genotypingLiquid-based thin-layer cytologyCombined detectionEarly screening for cervical cancerApplication value
万方数据
维普
