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EB病毒的生物学特点及致病机制

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EB病毒(Epstein-Barr virus,EBV)是一种DNA病毒,EB病毒感染在世界范围内常见,人群普遍易感,在我国主要影响学龄期儿童和青少年.该病毒可以通过潜伏感染的形式贮存于记忆性B细胞中,逃避人体免疫系统识别,使机体处于终身携带病毒状态.EB病毒与许多疾病有关,严重影响人类健康.本综述重点介绍了 EBV的生物学特点及致病机制,关注了该病毒如何与其宿主在肿瘤发生过程中的相互作用.
Biological Characteristics and Pathogenesis of the Epstein-Barr Virus
The Epstein-Barr virus(EBV)is a DNA virus.It is found commonly worldwide.The EBV can infect susceptible members of the general population.It mainly affects school-age children and adolescents in China.The EBV can be stored in memory B cells through latent infection,evading recognition by the human immune system and placing the body in a lifelong"carrier"state.The EBV is associated with several diseases and seriously affects human health.This review focuses on:(i)the biological characteristics and pathogenesis of the EBV;and(ii)how the EBV interacts with its host during tumor development.

Epstein-Barr virusImmune escapePathogenesisCancer inductionLymphomaEpithelial carcinoma

刘军、邓世明、刘铁陵、何顺芬、唐洪、卢蓉蓉

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绵阳市中医医院,绵阳 621000

EB病毒 免疫逃逸 致病机制 癌症诱导 淋巴瘤 上皮癌

2024

病毒学报
中国微生物学会

病毒学报

CSTPCD北大核心
影响因子:1.046
ISSN:1000-8721
年,卷(期):2024.40(4)