Diagnostic Value of Serum CRP,IgA and VEGF in Children with Severe Adenovirus Pneumonia
To explore the value of serum C-reactive protein(CRP),immunoglobulin A(IgA)and vascular endothelial growth factor(VEGF)in the early diagnosis of severe adenovirus pneumonia(SAP)in children,98 children with adenovirus pneumonia admitted to the Department of Pediatrics of Xinjiang Altay Regional People's Hospital from February 2020 to May 2023 were selected.The patients were divided into severe adenovirus pneumonia group(33 cases)and common adenovirus pneumonia group(65 cases).Peripheral venous blood was collected within 1 day after admission,and the levels of serum related indicators were detected,and the differences between the two groups were compared.The results showed that the age of children in the severe adenovirus pneumonia group was younger than that in the common adenovirus pneumonia group(P＜0.05),and the infection rate of mycoplasma pneumoniae,serum inflammation indexes TNF-α,IFN-γ,IL-6,CRP,MIP-1α,TGF-β1 and VEGF levels were significantly higher than those in the common adenovirus pneumonia group(P＜0.05).Serum IgA level was lower than that of common adenovirus pneumonia group(P＜0.05).Multivariate Logistic regression analysis confirmed age,mycoplasma pneumoniae infection,high CRP,VEGF,IFN-γ,TGF-β1 and low IgA as risk factors for SAP.Pearson correlation analysis showed that serum IgA expression was negatively correlated with SAP,CRP and VEGF were positively correlated with SAP expression.ROC curve analysis showed that the diagnostic efficiency of combined detection on SAP was higher than that of individual detection(P＜0.05).The results of this study indicate that serum CRP,VEGF and IgA are involved in the occurrence of SAP in children,and the combined detection can further improve its diagnostic efficiency.
Severe adenovirus pneumonia in childrenSerum C-reactive proteinImmunoglobulin AVascular endothelial growth factorIndicators of inflammationDiagnostic value
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