Research Progress on the Immune Regulation of ZBP1 and Patho-genic Infection
The core of innate immunity is the perception of pathogen-associated molecular patterns by cytoplasmic and membrane-associated receptors.Nucleic acids derived from infection or cell damage can cause an immune response if exposed to the cytoplasm.In addition to the classical mechanism of RNA sensing,research on the DNA-sensing system has also deepened gradually.Z-DNA binding protein 1(ZBP1)is a recently discovered cytosolic immunosensor of nucleic acids that positively regulates host type-1 interferon signals in a feedback loop,thereby amplifying the innate immune response.ZBP1 also plays an essential part in the innate immune response.ZBP1 binds specifically to the aberrantly accumulated Z-nucleic-acid through a special domain to stimulate necroptosis and promote programmed cell death to resist the invasion of pathogenic microorganisms.This review summarizes the physiological and pathological effects of ZBP1 protein.We focus on the protective and pathological immunoregulatory effects of ZBP1 in resistance to pathogen invasion.Our review provides new ideas for future research into the biological function of this protein.
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