Correlation between Combined Urinary Metal Exposure and Grip Strength under Three Statistical Models: A Cross-sectional Study in Rural Guangxi

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外文摘要：Objective This study aimed to investigate the potential relationship between urinary metals copper (Cu), arsenic (As), strontium (Sr), barium (Ba), iron (Fe), lead (Pb) and manganese (Mn) and grip strength. Methods We used linear regression models, quantile g-computation and Bayesian kernel machine regression (BKMR) to assess the relationship between metals and grip strength.Results In the multimetal linear regression, Cu (β=-2.119), As (β=-1.318), Sr (β=-2.480), Ba (β=0.781), Fe (β= 1.130) and Mn (β=-0.404) were significantly correlated with grip strength (P < 0.05). The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was -1.007 (95％ confidence interval:-1.362, -0.652; P < 0.001) when each quartile of the mixture of the seven metals was increased. Bayesian kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength, with Cu, As and Sr being negatively associated with grip strength levels. In the total population, potential interactions were observed between As and Mn and between Cu and Mn (Pinteractions of 0.003 and 0.018, respectively).Conclusion In summary, this study suggests that combined exposure to metal mixtures is negatively associated with grip strength. Cu, Sr and As were negatively correlated with grip strength levels, and there were potential interactions between As and Mn and between Cu and Mn.

外文关键词：

Urinary metalsHandgrip strengthQuantile g-computationBayesian kernel machine regression

作者：

LIANG Yu Jian、RONG Jia Hui、WANG Xue Xiu、CAI Jian Sheng、QIN Li Dong、LIU Qiu Mei、TANG Xu、MO Xiao Ting、WEI Yan Fei、LIN Yin Xia、HUANG Shen Xiang、LUO Ting Yu、GOU Ruo Yu、CAO Jie Jing、HUANG Chu Wu、LU Yu Fu、QIN Jian、ZHANG Zhi Yong

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作者单位：

Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University,Nanning 530021, Guangxi, China

Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University, Guilin 541199, Guangxi, China

Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin 541199, Guangxi, China

Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, Guangxi, China

Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning 530021, Guangxi, China

Key Laboratory of Longevity and Aging-related Diseases of Chinese Ministry of Education, Guang

Guangxi Health Commission Key Laboratory of Entire Lifecycle Health and Care, Guilin Medical University, Guilin 541199, Guangxi, China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaMajor Science and Technology Projects in GuangxiMajor Science and Technology Projects in GuangxiGuangxi Science and Technology Development ProjectGuangxi Science and Technology Development ProjectGuangxi Natural Science Foundation for Innovation Research TeamInnovation Platform and Talent Plan in GuilinGuangxi Scholarship Fund of Guangxi Education Department of China

项目编号：

81960583817605778156052382260629GKAA22399AA22096026AD 17129003180500052019GXNSFGA24500220220120-2

出版年：

2024

DOI：

10.3967/bes2024.002

生物医学与环境科学(英文版)

中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD

影响因子：0.76

ISSN：0895-3988

年,卷(期)：2024.37(1)

参考文献量64