首页|Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice

Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice

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Objective The aim of this study was to assess the impact of bisphenol A (BPA) and its substitute, bisphenol F (BPF), on the colonic fecal community structure and function of mice.Methods We exposed 6-8-week-old male C57BL/6 mice to 5 mg/(kg·day) and 50 μg/(kg·day) of BPA or BPF for 14 days. Fecal samples from the colon were analyzed using 16S rRNA sequencing. Results Gut microbiome community richness and diversity, species composition, and function were significantly altered in mice exposed to BPA or BPF. This change was characterized by elevated levels of Ruminococcaceae UCG-010 and Oscillibacter and decreased levels of Prevotella 9 and Streptococcus. Additionally, pathways related to carbohydrate and amino acid metabolism showed substantial enrichment. Conclusion Mice exposed to different BP analogs exhibited distinct gut bacterial community richness, composition, and related metabolic pathways. Considering the essential role of gut bacteria in maintaining intestinal homeostasis, our study highlights the intestinal toxicity of BPs in vertebrates.

Bisphenol A (BPA)Bisphenol F (BPF)16S rRNAMicrobiota

MENG Li Ying、TAO Wen Fu、LI Jing、ZHU Min、ZHONG De Bin、ZHOU Jing、QIN Xue、WEI Rong Guo

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Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China

Department of Clinical Laboratory, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China

Jiangsu Key Laboratory of Environmental Engineering, Jiangsu Academy of Environmental Sciences, Nanjing 210000, Jiangsu, China

Open Fund of the State Key Laboratory of Environmental Chemistry and EcotoxicologyGuangxi Zhuang Autonomous Region Health and Family Planning Commission Self-Financed Scientific Research ProjectGuangxi Zhuang Autonomous Region Health and Family Planning Commission Self-Financed Scientific Research ProjectGuangxi Medical and Health Key Discipline Construction Project

KF2020-13Z20200208Z-A20221124

2024

10.3967/bes2024.003

生物医学与环境科学(英文版)
中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD
影响因子：0.76
ISSN：0895-3988
年,卷(期)：2024.37(1)
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