首页|The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure

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Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in vivo.Methods Fluorescent microspheres (100 nm, 3 μm, and 10 μm) were given once at a dose of 200 mg/(kg·body weight). The fluorescence intensity (FI) in observed organs was measured using the IVIS Spectrum at 0.5, 1, 2, and 4 h after administration. Histopathology was performed to corroborate these findings.Results In the 100 nm group, the FI of the stomach and small intestine were highest at 0.5 h, and the FI of the large intestine, excrement, lung, kidney, liver, and skeletal muscles were highest at 4 h compared with the control group (P < 0.05). In the 3 μm group, the FI only increased in the lung at 2 h (P < 0.05). In the 10 μm group, the FI increased in the large intestine and excrement at 2 h, and in the kidney at 4 h (P < 0.05). The presence of nano-/microplastics in tissues was further verified by histopathology. The peak time of nanoplastic absorption in blood was confirmed.Conclusion Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however, only small amounts of MPs could penetrate the organs.

MicroplasticsNanoplasticsIVIS Spectrum small-animal imaging systemTissue distributionBlood

HONG Tao、SUN Wei、DENG Yuan、LYU Jian Da、JIN Cui Hong、BAI Ying Long、NA Jun、ZHANG Rui、GAO Yuan、PAN Guo Wei、YANG Zuo Sen、YAN Ling Jun

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Research Center for Universal Health, School of Public Health, China Medical University, Shenyang 110122,Liaoning, China

Department of Pain Management, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China

Department of Toxicology, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China

Department of Maternal and Child Health, School of Public Health, China Medical University, Shenyang 110122, Liaoning, China

Institute of Preventive Medicine, China Medical University, Shenyang 110122, Liaoning, China

Institute of Chronic Diseases, Liaoning Provincial Center for Disease Control and Prevention, Shenyang 110000, Liaoning, China

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National Natural Science Foundation of ChinaLiaoning Revitalization Talents ProgramKey R&D Program of Liaoning ProvinceKey Laboratory Program of Liaoning ProvinceKey Laboratory Program of Shenyang City

U21A20399XLYC18020592019JH2/10300044201822511321-103-0-16

2024

10.3967/bes2024.004

生物医学与环境科学(英文版)
中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD
影响因子：0.76
ISSN：0895-3988
年,卷(期)：2024.37(1)
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