首页|Epidemiological Surveillance:Genetic Diversity of Rotavirus Group A in the Pearl River Delta,Guangdong,China in 2019

Epidemiological Surveillance:Genetic Diversity of Rotavirus Group A in the Pearl River Delta,Guangdong,China in 2019

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Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,China.Methods This study included individuals aged 28 days-85 years.A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens,including RVA,using a Gastrointestinal Pathogen Panel,followed by genotyping,virus isolation,and complete sequencing to assess the genetic diversity of RVA.Results The overall RVA infection rate was 14.59%(103/706),with an irregular epidemiological pattern.The proportion of co-infection with RVA and other pathogens was 39.81%(41/103).Acute gastroenteritis is highly prevalent in young children aged 0-1 year,and RVA is the key pathogen circulating in patients 6-10 months of age with diarrhea.G9P[8](58.25%,60/103)was found to be the predominant genotype in the RVA strains,and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic analysis.Recombination analysis showed that gene reassortment events,selection pressure,codon usage bias,gene polymorphism,and post-translational modifications(PTMs)occurred in the G9P[8]and G3P[8]strains.Conclusion This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China,further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic diversity.Strengthening the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.

Infectious diarrheal diseaseRotavirusPhylogenetic analysisGene rearrangementCodon usage biasGenetic diversity

JIANG Jie Ying、LIANG Dan、WANG Li、XIAO Yun、LIANG Yu Feng、KE Bi Xia、SU Juan、XIAO Hong、WANG Tao、ZOU Min、LI Hong Jian、KE Chang Wen

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School of Public Health,Shantou University,Shantou 515063,Guangdong,China

Guangdong Provincial Center for Disease Control and Prevention,Guangdong Workstation for Emerging Infectious Disease Control and Prevention,Guangzhou 511430,Guangdong,China

Guangdong Provincial Key Laboratory of Virology,Institute of Medical Microbiology,Jinan University,Guangzhou 510632,Guangdong,China

School of Public Health,Sun Yat-sen University,Guangzhou 510275,Guangdong,China

School of Public Health,Southern Medical University,Guangzhou 510515,Guangdong,China

Shantou University Medical College,Shantou 515041,Guangdong,China

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National Key Research and Development Program of ChinaNational Key Research and Development Program of China广东省科技计划广东省科技计划

2017ZX10103011-0042018YFC16038042018B0202070132019B030316013

2024

生物医学与环境科学(英文版)
中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD
影响因子:0.76
ISSN:0895-3988
年,卷(期):2024.37(3)
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