首页|Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB
Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB
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Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and CD86.Method This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results In total,143 patients were enrolled(NH group,n = 49;NA group,n = 47;P group,n = 47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<0.001.Conclusion Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.
YANG Liu、WANG Shi Yu、JIANG Ting Ting、DENG Wen、CHANG Min、WU Shu Ling、CAO Wei Hua、LU Yao、SHEN Ge、LIU Ru Yu、GAO Yuan Jiao、XU Meng Jiao、HU Lei Ping、ZHANG Lu、XIE Yao、LI Ming Hui
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Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China
Center for Infectious Diseases,Second Affiliated Hospital of Air Force Medical University,Xi'an 710038,Shaanxi,China
Department of Hepatology Division 2,Peking University Ditan Teaching Hospital,Beijing 100015,China
国家重点研发计划国家重点研发计划Capital Clinical Diagnostic Techniques and Translational Application ProjectsCapital's Funds for Health Improvement and ResearchBeijing Hospitals Authority Clinical Medicine Development of Special Funding Support国家科技重大专项
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