Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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外文摘要：Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical indicators.Method The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with DILI.Based on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),anti-infective drugs,and other drugs,patients were divided into five groups.Cytokines were measured by Luminex technology.Baseline characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were analyzed.Results 73 patients were enrolled.Age among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine group.Interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs group.There was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs group.Conclusion Older age may be more prone to DILI.Patients with NSAIDs have more severe liver damage in early stages of DILI,TNF-α and IL-6 may partake the inflammatory process of DILI.

外文关键词：

Drug-induced liver injuryCytokinesNon-steroidal anti-inflammatory drugsInflammation

作者：

CAO Wei Hua、JIANG Ting Ting、SHEN Ge、DENG Wen、WANG Shi Yu、ZHANG Zi Yu、LI Xin Xin、LU Yao、ZHANG Lu、LIU Ru Yu、CHANG Min、WU Shu Ling、GAO Yuan Jiao、HAO Hong Xiao、CHEN Xiao Xue、HU Lei Ping、XU Meng Jiao、YI Wei、XIE Yao、LI Ming Hui

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作者单位：

Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China

Department of Gynecology and Obstetrics,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China

Department of Hepatology Division 2,Peking University Ditan Teaching Hospital,Beijing 100015,China

基金：

国家重点研发计划国家重点研发计划Beijing Municipal Health Commission High-level public health technical personnel construction projectBeijing Hospitals Authority Clinical Medicine Development of Special Funding SupportDigestive Medical Coordinated Development Center of Beijing Hospitals AuthorityCapital Health Development and Research of Special

项目编号：

2022YFC26035002022YFC2603505discipline leader-03-26XMLX 202127XXZ03022022-1-2172

出版年：

2024

DOI：

10.3967/bes2024.054

生物医学与环境科学(英文版)

中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD

影响因子：0.76

ISSN：0895-3988

年,卷(期)：2024.37(5)