Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix

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外文摘要：Objective Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma(CSCC).Methods Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC immunotherapy.RNA Sequencing was performed to analyze neoantigen expression.Results Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in CSCCs.Missense mutations were the most frequent types of somatic mutation in the coding sequence regions.Mutational signature analysis detected signature 2,signature 6,and signature 7 in CSCC samples.PIK3CA,FBXW7,and BICRA were identified as potential driver genes,with BICRA as a newly reported gene.Genomic variation profiling identified 4,960 potential neoantigens,of which 114 were listed in two neoantigen-related databases.Conclusion The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.

外文关键词：

Cervical squamous cell carcinomaGenome alterationNeoantigensImmunotherapy

作者：

Meng Wu、Jialu Zhou、Zhe Zhang、Yuanguang Meng

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作者单位：

School of Medicine,Nankai University,Tianjin 300071,China

Department of Obstetrics and Gynecology,The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China

Department of Obstetrics and Gynecology,Chinese PLA Medical School,Beijing 100853,China

Department of Obstetrics and Gynecology,The Seventh Medical Center of Chinese PLA General Hospital,Beijing 100700,China

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出版年：

2024

DOI：

10.3967/bes2024.064

生物医学与环境科学(英文版)

中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD

影响因子：0.76

ISSN：0895-3988

年,卷(期)：2024.37(6)