SiO2 Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model

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外文摘要：Objective The aim of this study was to explore the role and mechanism of ferroptosis in SiO2-induced cardiac injury using a mouse model.Methods Male C57BL/6 mice were intratracheally instilled with SiO2 to create a silicosis model.Ferrostatin-1(Fer-1)and deferoxamine(DFO)were used to suppress ferroptosis.Serum biomarkers,oxidative stress markers,histopathology,iron content,and the expression of ferroptosis-related proteins were assessed.Results SiO2 altered serum cardiac injury biomarkers,oxidative stress,iron accumulation,and ferroptosis markers in myocardial tissue.Fer-1 and DFO reduced lipid peroxidation and iron overload,and alleviated SiO2-induced mitochondrial damage and myocardial injury.SiO2 inhibited Nuclear factor erythroid 2-related factor 2(Nrf2)and its downstream antioxidant genes,while Fer-1 more potently reactivated Nrf2 compared to DFO.Conclusion Iron overload-induced ferroptosis contributes to SiO2-induced cardiac injury.Targeting ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO2 cardiotoxicity,potentially via modulation of the Nrf2 pathway.

外文关键词：

SiO2 exposureIron overloadFerroptosisCardiac injuryNrf2

作者：

Yongheng Wang、Ning Li、Yi Guan、Tong LI、Yuxiu Zhang、Hong Cao、Zhihua Yu、Zhiheng Li、Shuoyan Li、Jiahao Hu、Wenxin Zhou、Sisi Qin、Shuang Li、Sanqiao Yao

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作者单位：

School of Public Health,North China University of Science and Technology,Tangshan 063210,Hebei,China

Hebei Key Laboratory of Occupational Health and Safety for Coal Industry,North China University of Science and Technology,Tangshan 063210,Hebei,China

Occupational Disease Prevention and Control Institute of Jinneng Holding Coal Industry Group Co.,Ltd,Datong 037001,Shanxi,China

China Pingmei Shenma Group Occupational Disease Prevention and Control Hospital,Pingdingshan 467000,Henan,China

School of Public Health,Xinxiang Medical University,Xinxiang 453003,Henan,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaHebei Provincial Department of Science and Technology Centrally Guided Local Development Fund ProjectOccupational health risk assessment and the formulation of national occupational health standards

项目编号：

U21A2033482373544236Z7705G102393220020090000020

出版年：

2024

DOI：

10.3967/bes2024.087

生物医学与环境科学(英文版)

中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD

影响因子：0.76

ISSN：0895-3988

年,卷(期)：2024.37(6)