首页|Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection

Research Progress on the Association between Schizophrenia and Toxoplasma gondii Infection

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Toxoplasma gondii(T.gondii or Tg),is an obligatory intracellular parasite with humans as its intermediate hosts.In recent years,significant correlations between T.gondii infection and schizophrenia have been reported,including the possible mediating mechanisms.Currently,mechanisms and hypotheses focus on central neurotransmitters,immunity,neuroinflammation,and epigenetics;however,the exact underlying mechanisms remain unclear.In this article,we review the studies related to T.gondii infection and schizophrenia,particularly the latest research progress.Research on dopamine(DA)and other neurotransmitters,the blood-brain barrier,inflammatory factors,disease heterogeneity,and other confounders is also discussed.In addition,we also summarized the results of some new epidemiological investigations.

Toxoplasma gondiiSchizophreniaNeurotransmittersNeuroinflammationImmunityEpigenetics

Yiting Zhu、Xiaohui Yang、Miaoru Chen、Yu Hu、Yunfeng Chang、Xiang Wu

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Department of Forensic Medicine Science,Xiangya School of Basic Medicine,Central South University,Changsha 410013,Hunan,China

Nursing Department,The Third Xiangya Hospital of Central South University,Changsha 410013,Hunan,China

Department of Basic Medicine Science,Xiangya School of Basic Medicine,Central South University,Changsha 410013,Hunan,China

Department of Parasitology,Xiangya School of Basic Medicine,Central South University,Changsha 410013,Hunan,China

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National Natural Sciences Foundation of ChinaNational Natural Sciences Foundation of ChinaNational Key Research and Development Program of China

82072306323701972022YFC2304000

2024

10.3967/bes2024.071

生物医学与环境科学(英文版)
中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD
影响因子：0.76
ISSN：0895-3988
年,卷(期)：2024.37(6)
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