首页|Original Article Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai
Original Article Impact of Air Pollutants on Lung Function and Inflammatory Response in Asthma in Shanghai
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
Objective Air pollution is a leading public health issue.This study investigated the effect of air quality and pollutants on pulmonary function and inflammation in patients with asthma in Shanghai.Methods The study monitored 27 asthma outpatients for a year,collecting data on weather,patient self-management[daily asthma diary,peak expiratory flow(PEF)monitoring,medication usage],spirometry and serum markers.To explore the potential mechanisms of any effects,asthmatic mice induced by ovalbumin(OVA)were exposed to PM2.5.Results Statistical and correlational analyses revealed that air pollutants have both acute and chronic effects on asthma.Acute exposure showed a correlation between PEF and levels of ozone(O3)and nitrogen dioxide(NO2).Chronic exposure indicated that interleukin-5(IL-5)and interleukin-13(IL-13)levels correlated with PM2.5 and PM10 concentrations.In asthmatic mouse models,exposure to PM2.5 increased cytokine levels and worsened lung function.Additionally,PM2.5 exposure inhibited cell proliferation by blocking the NF-κB and ERK phosphorylation pathways.Conclusion Ambient air pollutants exacerbate asthma by worsening lung function and enhancing Th2-mediated inflammation.Specifically,PM2.5 significantly contributes to these adverse effects.Further research is needed to elucidate the mechanisms by which PM2.5 impacts asthma.
Ambient air pollutantsAcute and chronic effects on asthmaPM2.5OVA-induced asthmatic mice
Guifang Wang、Youzhi Zhang、Haiyan Yang、Yi Yang、Liang Dong、Peng Zhang、Jie Liu、Xiaodong Chen、Yi Gong
展开 >
Department of Respiratory and Critical Care Medicine,Quzhou People's Hospital,Quzhou 324000,Zhejiang,China
Department of Respiratory and Critical Care Medicine,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China
Centre of Hydrogen Science,Shanghai Jiao Tong University&Key Lab of Hydrogen Science,Shanghai 200240,China
Department of Respiratory and Critical Care Medicine,Shanghai Public Health Clinical Centre,Fudan University,Shanghai 201508,China
展开 >
Shanghai Science and Technology Commission with ProjectShanghai Science and Technology Commission with Project
NETL
NSTL
万方数据
