首页|Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang,China

Disparities in the Levels of Whole-Blood Epstein-Barr Virus between the Cancer and Non-Cancer Populations in Zhejiang,China

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Objective This study aimed to investigate the prevalence of Epstein-Barr virus (EBV) infection in patients with and without cancer.Methods A total of 26,648 participants who underwent whole-blood EBV DNA (WBEBV) assays between January 1,2020,and August 31,2023,were included. The chi-square test was used for categorical data analysis,and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of WBEBV.Results Positive rates were 10.2％ and 25.4％ for healthy controls (HC) and patients,respectively. The positivity rate for EBV-associated neoplasms (EN) was the highest at 7.53％,followed by leukemia (Le) at 5.49％. The subgroup analysis showed that the positivity rate for abnormal proliferation or hyperplasia (APH) was 31.9％,followed by 30.5％ for Le. The WBEBV of patients with transplants (TP),especially living-related transplants (LT),was the highest among all subgroups. WBEBV at diagnosis was used to differentiate between infectious mononucleosis (IM) and chronic active Epstein-Barr virus (CAEBV),with a sensitivity of 67.4％ (95％ confidence interval[CI]:57.6-75.8) and specificity of 72％ (95％ CI:63.3-79.3). We conclude that the prevalence of EBV infection is low in the healthy population in this region and that a high EBV load at baseline is more common in LT,IM,and Lymphocyte Leukemia (LL). Conclusion This study used a large-sample survey to characterize the prevalence of whole-blood EBV levels in various diseases,including the stages and subtypes. The EBV detection rate was higher in patients with malignant disease than in those with benign disease. Our study provides clinicians with baseline information regarding EBV-associated diseases.

Epstein-Barr virusEpstein-Barr virus DNAWhole blood Epstein-Barr virus DNAViral load

Qingjun Jia、Meichun Zeng、Qi Chen

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Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution),Hangzhou 310021,Zhejiang,China

Department of Pathology,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang,China

Hangzhou Medical Health Science and Technology ProjectSpecial Supporting Program of Agriculture and Social Development from Hangzhou Municipal Science&Technology Bureau

A20220558202203B34

2024

10.3967/bes2024.101

生物医学与环境科学(英文版)
中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD
影响因子：0.76
ISSN：0895-3988
年,卷(期)：2024.37(9)