首页|Association between Metal(loid)Exposure and Risk of Polycystic Ovary Syndrome Mediated by Anti-Müllerian Hormone among Women Undergoing In Vitro Fertilization and Embryo Transfer

Association between Metal(loid)Exposure and Risk of Polycystic Ovary Syndrome Mediated by Anti-Müllerian Hormone among Women Undergoing In Vitro Fertilization and Embryo Transfer

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Objective To investigate the relationship and potential pathways between metal(loid)exposure and the risk of polycystic ovary syndrome(PCOS)in women of childbearing age.Methods This case-control study included 200 patients with PCOS(cases)and 896 non-PCOS controls with the age of 25-37 years.The concentrations of 29 metal(loid)s in the follicular fluid(FF)and clinical indicators in the serum were measured in all participants.Logistic regression analysis and mediation analysis were conducted to evaluate the associations between metal(loid)exposure and PCOS risk and investigate the possible roles of clinical indicators,respectively.Results Logistic regression analysis revealed an association between high copper levels in FF and increased PCOS risk(highest vs.lowest quartile:adjusted odds ratio=2.94,95%confidence interval:1.83-4.72).A high luteinizing hormone/follicle-stimulating hormone ratio and elevated levels of testosterone and anti-Müllerian hormone(AMH)were strongly associated with increased PCOS risk induced by high copper exposure.The mediation analysis indicated a mediating effect of AMH in the association between copper exposure and PCOS risk.Conclusion Copper may affect PCOS risk through the hypothalamic-pituitary-ovarian axis,mediated by AMH.Copper exposure and internal AMH levels are important indicators for early warning of PCOS development.

CopperPolycystic ovary syndromeAnti-Müllerian hormoneInfertilityWomen of childbearing age

Shu Su、Mengyuan Ren、Yanqiu Feng、Changxin Lan、Lailai Yan、Qun Lu、Jia Xu、Bin Han、Lili Zhuang、Mingliang Fang、Bin Wang、Hongchu Bao、Bo Pan

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Institute of Reproductive and Child Health,Peking University/Key Laboratory of Reproductive Health,National Health Commission of the People's Republic of China,Beijing 100191,China

Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China

Department of Laboratorial Science and Technology,School of Public Health,Peking University,Beijing 100191,China

Medical Center for Human Reproduction,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China

State Key Laboratory of Environmental Criteria and Risk Assessment,Chinese Research Academy of Environmental Sciences,Beijing 100012,China

Reproductive Medicine Center,The Affliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264000,Shandong,China

Department of Environmental Science and Engineering,Fudan University,Shanghai 200433,China

Key Laboratory of Epidemiology of Major Diseases(Peking University),Ministry of Education,Beijing 100191,China

Laboratory for Earth Surface Processes,College of Urban and Environmental Science,Peking University,Beijing 1008

Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control,Faculty of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650500,Yunnan,China

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National Key Research&Development Program of the Ministry of Science and Technology of ChinaNational Key Research&Development Program of the Ministry of Science and Technology of ChinaStrategy Priority Research Program(Category B)of Chinese Academy of SciencesYunnan Major Scientific and Technological ProjectsNational Natural Science Foundation of China

2022YFE01349002023YFC3708305XDB0750300202202AG05001942077390

2024

10.3967/bes2024.154

生物医学与环境科学(英文版)
中国疾病预防控制中心

生物医学与环境科学(英文版)

CSTPCD
影响因子：0.76
ISSN：0895-3988
年,卷(期)：2024.37(10)