Protective effect and mechanism of rhodiola bionic nano-drug on pancreatic injury in rats with acute pancreatitis
Objective:To explore the mechanism of protecting pancreatic injury in rats with acute pancreatitis by using rhodiola bionic nano-drug.Methods:Forty rats were randomly divided into four groups with 10 rats in each group.Control group:normal rats,model group:acute pancreatitis rat model,rhodiola group:simple rhodiola drug treatment;Nano-treatment group:Rhodiola was treated with bionic nano-medicine.Except for the control group,the other three groups established rat models of acute pancreatitis.The mRNA values of transforming growth factor β1 (TGF-β1 ),transforming growth factor β1 receptor Ⅱ(TβRⅡ)and Smad3 mRNA mice of each group were measured at 12 hours,24 hours and 48 hours after the model medication,and the collagen type Ⅰ(ColⅠ)in pancreatic tissue was detected.Results:The mrna values of TGF-β1,TβRⅡ and Smad3 mRNA the model group increased after 12 hours of modeling,decreased at 24 hours,and increased again at 48 hours.The indexes of rhodiola sachalinensis group and nano-therapy group were lower than those of model group,and nano-therapy group was lower than that of rhodiola sachalinensis group (P<0.05 ),while serum amylase and ColⅠ ⅰ of rhodiola sachalinensis group and nano-therapy group were lower than those of model group,and nano-therapy group was lower than that of rhodiola sachalinensis group (P<0.05).Conclusion:Rhodiola's bionic nano-drug has a good effect in the treatment of acute pancreatitis in rats,which can improve tissue damage and promote repair. The drug has a protective mechanism on pancreatic tissue.
万方数据
维普
