Exploring the effects of Astragalus membranaceus on cognitive function in Alzheimer's disease rats based on the JNK/p38 MAPK signaling pathway
Objective:To explore the effect of Astragalus membranaceus on cognitive function in Alzheimer's disease rats based on the JNK/p38 MAPK signaling pathway.Method:Sixty Wistar rats were selected as the experimental subjects of this study,with 15 rats as the control group.The remaining rats were divided into a model group (15 rats ), a Western medicine treatment group (15 rats ), and an Astragalus membranaceus treatment group (15 rats),each treated with 0.9％ NaCl,donepezil hydrochloride,and Astragalus membranaceus IV.Compare the changes in various aspects of the four groups of rats.Result:The expression levels of JNK and p38 MAPK in the control group were lower than those in the other three groups,and the expression levels of JNK and p38 MAPK in the Huangqi treatment group were lower than those in the model group and the Western medicine treatment group,with significant differences (P<0.05);The levels of inflammatory factors in the control group were lower than those in the other three groups,and the levels of inflammatory factors in the Huangqi treatment group were lower than those in the model group and the Western medicine treatment group (P<0.05);The results of the Morris water maze experiment on days 2,3,and 4 in the control group were superior to the other three groups,and the results of the Morris water maze experiment on days 2 ,3 ,and 4 in the astragalus treatment group were superior to the model group and the Western medicine treatment group,with significant differences (P<0.05);The total exploration time during the testing period of the control group's New Object Recognition (NOR) experiment was shorter than the other three groups,and the preference index for new objects was higher than the other three groups;Moreover,the total exploration practice during the testing period of the New Object Recognition (NOR)experiment in the Huangqi treatment group was shorter than that in the model group and the Western medicine treatment group,and the preference index for new objects was higher than that in the model group and the Western medicine treatment group,with significant differences (P<0.05). Conclusion:Huangqi treatment has advantages in improving cognitive function in Alzheimer's rats,and its drug mechanism of action is related to the JNK/p38 MAPK signaling pathway.
Alzheimer's diseaseAstragalus membranaceusJNK/p38 MAPK signaling pathwaycognitive function
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