Analysis of rapid detection results of sulfonylurea in hypoglycemic proprietary Chinese medicine by different methods
Objective:To explore the rapid detection results of sulfonylurea in hypoglycemic proprietary Chinese medicine by thin layer chromatography(TIC)and test tube reaction.Methods:Hypoglycemic proprietary Chinese medicine was selected as the research object.Liquid phase mass spectrometry(LC-MS)was used as the gold standard to determine the sulfonylurea components in drugs.TIC test method and test-tube reaction method were used for rapid detection of all drugs,and the final detection results were compared to compare the sensitivity,specificity and coincidence rate of the two detection methods.Results:Compared with the two rapid detection methods,the coincidence rate of the test tube reaction method was higher(P＜0.05),although the sensitivity and specificity of the two methods were higher than that of the test tube reaction method,but there was no significant difference(P＞0.05).Conclusion:In the detection of the addition of sulfonylurea components in hypoglycemic Chinese patent medicines,the test tube reaction method has better results,which is more suitable for field inspection.
hypoglycemic proprietary Chinese medicineSulfonylurea componentsTICtest tube reaction methodrapid detection
万方数据
维普
