Research Method:The "Adolescent Physical Activity Scale,""Academic Self Efficacy Scale,""Emotional Intelligence Scale," and "Self Rating Depression Scale" were used to measure 1987 high school students,and SPSS 19.0 and AMOS 17.0 were used for statistical analysis of the data.Research conclusion:Physical activity has a significant effect on suppressing adolescent depression.Emotional intelligence and academic self-efficacy have significant individual and chain mediated partial mediating effects between adolescent physical activity and depression,which can be suppressed by enhancing adolescent emotional intelligence and academic self-efficacy as individual and chain mediated effects.