北京化工大学学报(自然科学版)2024,Vol.51Issue(1) :76-83.DOI:10.13543/j.bhxbzr.2024.01.009

Fe3O4@CTAC粒子的制备及抗菌性能研究

Preparation and antibacterial properties of Fe3O4@CTAC particles

李楠 许伟坚 苑金磊 刘长霞
北京化工大学学报(自然科学版)2024,Vol.51Issue(1) :76-83.DOI:10.13543/j.bhxbzr.2024.01.009

Fe3O4@CTAC粒子的制备及抗菌性能研究

Preparation and antibacterial properties of Fe3O4@CTAC particles

李楠 1许伟坚 1苑金磊 1刘长霞1
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作者信息

  • 1. 北京化工大学 生命科学与技术学院,北京 100029
  • 折叠

摘要

采用溶剂热法合成了分散性良好的Fe3O4 粒子,然后将油酸修饰到Fe3O4 粒子表面,再通过疏水作用进行十六烷基三甲基氯化铵(CTAC)包覆,得到Fe3O4@CTAC粒子.采用扫描电子显微镜(SEM)、X射线光电子能谱(XPS)、X射线衍射(XRD)、Zeta电位和振动样品磁强计(VSM)对Fe3O4@CTAC粒子进行了表征,结果表明:Fe3O4粒子表面包覆CTAC后粒径无明显变化,并且仍保持良好的单分散性;Fe3O4@CTAC粒子具有超顺磁性和良好的磁响应性能;Fe3O4@CTAC粒子的Zeta电位较高,分散体系具有较好的稳定性.对Fe3O4@CTAC粒子进行了抗菌性能及磁分离去除菌体测试,结果显示:当 Fe3O4@CTAC 粒子的含量为 50 mg/mL 时,与大肠杆菌(E.coli)(105 cfu/mL)作用10 min,抗菌率可达100%;Fe3O4@CTAC粒子对E.coli、金黄色葡萄球菌(S.aureus)及枯草芽孢杆菌(B.subtilis)均具有良好的抗菌效果;通过磁场分离可以将Fe3O4@CTAC粒子及吸附的菌体去除.以上结果表明Fe3O4@CTAC粒子是一种快速、高效、可以实现无菌体残留的抗菌剂,具有潜在的应用价值.

Abstract

Fe3O4 particles with good dispersibility were synthesized by a solvothermal method.The surface of the Fe3O4 particles was first modified with oleic acid and cetyltrimethylammonium chloride(CTAC)was then coated via hydrophobic interactions to obtain Fe3O4@CTAC particles.The Fe3O4@CTAC particles were characterized by scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),Zeta potential measurements and vibrating sample magnetometry(VSM).The results show that the particle size of Fe3O4 has no obvious change after coating with CTAC,and the Fe3O4@CTAC particles retain good monodispersity.The Fe3O4@CTAC particles have superparamagnetism and good magnetic response properties.The Zeta potential of Fe3O4@CTAC particles is high,and the dispersion has good stability.The antibacterial properties and magnetic separation of Fe3O4@CTAC particles were tested.The results showed that when 50 mg/mL Fe3O4@CTAC particles were treated with E.coli(105 cfu/mL)for10min,the antibacterial rate could reach100%.Fe3O4@CTAC parti-cles also have good antibacterial effects on S.aureus and B.subtilis.The Fe3O4@CTAC particles and adsorbed bacteria can be separated using a magnetic field.The above results indicate that Fe3O4@CTAC is a fast,efficient antibacterial agent that can generate aseptic residues and thus has potential application value.

关键词

磁性Fe3O4粒子/十六烷基三甲基氯化铵(CTAC)/Fe3O4@CTAC/大肠杆菌/抗菌性能

Key words

magnetic Fe3O4 particles/cetyltrimethylammonium chloride(CTAC)/Fe3O4@CTAC/E.coli/anti-bacterial property

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基金项目

国家留学基金(202006885026)

出版年

2024
北京化工大学学报(自然科学版)
北京化工大学

北京化工大学学报(自然科学版)

CSTPCDCSCD北大核心
影响因子:0.399
ISSN:1671-4628
参考文献量37
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