Risk factors and Nomogram prediction model for surgical site infection after radical surgery with tissue flap transplantation in patients with primary moderate-advanced oral cancer
Objective To analysis the risk factors of surgical site infection(SSI)after radical surgery with tissue flap transplantation in patients with primary moderate-advanced oral cancer,and to establish a risk prediction model by nomogram.Methods Patients firstly diagnosed with primary moderate-advanced oral squamous cell carcinoma in Beijing Stomatological Hospital,Capital Medical University from March 2015 to March 2020 were enrolled.The baseline data,intraoperative data,information of SSI were collected.Multivariate Logistic regression analysis was used to determine the risk factors for SSI,and a nomogram model was established.ROC curves,Calibration curves,Hosmer-Lemeshow test,and Decision Curve Analysis(DCA)were used to evaluate the discrimination,calibration,and the clinical value of the nomogram model.Results A total of 360 patients were enrolled in this study.83(23.1%)of the patients suffered from SSI.History of diabetes,tumor location,T4b stage,operation time≥8.0h and tracheostomy were determined as independent risk factors for SSI by multivariate logistic regression analysis.The C-index of the model was 0.682,the P value of Hosmer Lemeshow test was 0.974.Decision curve confirmed net benefit for patients of this model in the analysis.Conclusions The risk factors of surgical site infection after radical surgery with tissue flap transplantation in patients with primary moderate-advanced oral cancer were determined in this study.The nomogram model was established and showed a reliable ability in predicting the occurrence of SSI and guiding value in clinical work.
维普
万方数据
