Anti-bacterial effects of modified magnesium-based hydrotalcite
Magnesium-based hydrotalcite(MAL),aspartic acid(ASP)-loaded hydrotalcite(MALA),ASP and Ag+co-loaded hydrotalcite(MALAA)were prepared by nucleation crystallisation,their hydrotalcite structure and morphology were characterised by X-ray diffraction and transmission electron microscopy.Both ASP and Ag+were found successfully loaded onto MAL with morphological changes.Their antibacterial effect on Staphylococcus aureus(S.aureus)was examined by colony counting method.MAL inhibition of S.aureus growth was found to be 5.8％at 4 mg·mL-1,but MALAA inhibition was 99.7％.The anti-bacterial mechanism of these modified magnesium-based hydrotalcites was examined by inductively coupled plasma and UV-visible spectrophotometer techniques.MALA was found adsorbed electrostatically on the negatively charged S.aureus,with changed MALA morphology,to increase the overall contact area with bacteria.Introduction of Ag+,by increasing the potential difference between MALAA and the bacterial cell surface,promoted the rupture of S.aureus cell membrane,leading to significantly-increased extracellular cations(K+,Ca2+,and Mg2+)and proteins.MALA but especially MALAA due to their antibacterial activities will be very useful packing materials in the food,cosmetics industries.
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